ASSESSMENT OF CORRELATION BETWEEN PRO-INFLAMMATORY CYTOKINE (INTERLEUKIN-1 α, β) GENE POLYMORPHISMS AND CHRONIC PERIODONTITIS

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AMINI SHIRIN; GOLESTANEH HEDAYATOLLAH; JALILZADEH SHAHRAM; GHAFARI MOHAMMADREZA; RAMIM TAYEB

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Journal: Journal of Isfahan Dental School Year:2013 | Volume:9 | Issue:5 Page(s): 393-401

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Title

ASSESSMENT OF CORRELATION BETWEEN PRO-INFLAMMATORY CYTOKINE (INTERLEUKIN-1 α, β) GENE POLYMORPHISMS AND CHRONIC PERIODONTITIS

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Keywords

CHRONIC PERIODONTITISQ2

GENETIC POLYMORPHISMQ2

GENOTYPEQ2

IL-1αQ2

IL-1βQ2

Abstract

Introduction: Periodontal diseases are multifactorial conditions that are induced in the presence of bacteria and under the influence of environmental and genetic factors. Management of environmental factors might help prevent such diseases. The aim of this study was to investigate the relationship between interleukin-1a, b gene polymorphism and CHRONIC PERIODONTITIS (CP).Materials and Methods: This case-control study included 36 subjects with CHRONIC PERIODONTITIS referred to Periodontology Department of Khorasgan Dental School and 36 periodontally healthy controls, with an ethnic origin of Isfahani Iranian race. Extracted DNA from peripheral blood was used to evaluate interleukin-1a, b gene polymorphism. Data were analyzed using chi-squared and Fisher’s exact tests (a=0.05).Results: There was a significant association between IL-1a -889, 2.2 GENOTYPE and CP and between IL-1a -889 allele and periodontal health (p value = 0.03). There was no significant association between IL-1b +3954 GENOTYPE and CP (p value = 0.14). There was no significant association between IL-1b +3954 alleles and CP (p value = 0.06).Conclusion: Based on the results of the present study, association between IL-1a -889 polymorphism in the population presented here confirms this gene as a risk factor for CP. However, the lack of any association between IL-1b +3954 polymorphism and CP makes it dubious to use this gene as a marker of susceptibility to CP.

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APA: Copy

AMINI, SHIRIN, GOLESTANEH, HEDAYATOLLAH, JALILZADEH, SHAHRAM, GHAFARI, MOHAMMADREZA, & RAMIM, TAYEB. (2013). ASSESSMENT OF CORRELATION BETWEEN PRO-INFLAMMATORY CYTOKINE (INTERLEUKIN-1 α, β) GENE POLYMORPHISMS AND CHRONIC PERIODONTITIS. JOURNAL OF ISFAHAN DENTAL SCHOOL, 9(5), 393-401. SID. https://sid.ir/paper/126384/en

Vancouver: Copy

AMINI SHIRIN, GOLESTANEH HEDAYATOLLAH, JALILZADEH SHAHRAM, GHAFARI MOHAMMADREZA, RAMIM TAYEB. ASSESSMENT OF CORRELATION BETWEEN PRO-INFLAMMATORY CYTOKINE (INTERLEUKIN-1 α, β) GENE POLYMORPHISMS AND CHRONIC PERIODONTITIS. JOURNAL OF ISFAHAN DENTAL SCHOOL[Internet]. 2013;9(5):393-401. Available from: https://sid.ir/paper/126384/en

IEEE: Copy

SHIRIN AMINI, HEDAYATOLLAH GOLESTANEH, SHAHRAM JALILZADEH, MOHAMMADREZA GHAFARI, and TAYEB RAMIM, “ASSESSMENT OF CORRELATION BETWEEN PRO-INFLAMMATORY CYTOKINE (INTERLEUKIN-1 α, β) GENE POLYMORPHISMS AND CHRONIC PERIODONTITIS,” JOURNAL OF ISFAHAN DENTAL SCHOOL, vol. 9, no. 5, pp. 393–401, 2013, [Online]. Available: https://sid.ir/paper/126384/en

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