EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT

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MOAZEDI A.A.; SAMIEI F.; CHINIPARDAZ R.

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Journal: Jundishapur Scientific Medical Journal Year:2003 | Volume:- | Issue:35 Page(s): 41-49

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Title

EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT

Author(s)

MOAZEDI A.A. | SAMIEI F. | CHINIPARDAZ R. | Issue Writer Certificate

Keywords

CHOLESTROLQ3

LOVASTATIONQ3

T-MAZEQ3

SPATIAL LEARNINGQ3

RATQ2

Abstract

In this study the effect of CHOLESTROL and LOVASTATION on SPATIAL LEARNING task, was investigated by using T-MAZE in male N-MARI RATs. The animals were divided into four groups; the first group were fed with diets containing %5 cholesterol at libitum for 7 days, and second group were fed with LOVASTATION (30mg/kg/day) for 9 days after administration of %5 CHOLESTROL for 7 days, and the third group only were received LOVASTATION (30mg/kg) for 9 days. The fourth group as a control were fed with lab chow diet.The results showed that administration of dietary CHOLESTROL for one week decreased SPATIAL LEARNING (P<0.05) in comparison with control group. On the other hand, the RATs fed with LOVASTATION increased SPATIAL LEARNING task (P<0.05).The facilitative effect of LOVASTATION prior to training may be due to decreasing of CHOLESTROL. It is assumed that CHOLESTROL produces learning defect, probably by decrease fluidity of membranee, influence on activity of neurotransmitter receptors, ionic channel and also learning activities.

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References

THE EFFECTS OF CORN OIL ON SPATIAL LEARNING IN RAT

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APA: Copy

MOAZEDI, A.A., SAMIEI, F., & CHINIPARDAZ, R.. (2003). EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, -(35), 41-49. SID. https://sid.ir/paper/12813/en

Vancouver: Copy

MOAZEDI A.A., SAMIEI F., CHINIPARDAZ R.. EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2003;-(35):41-49. Available from: https://sid.ir/paper/12813/en

IEEE: Copy

A.A. MOAZEDI, F. SAMIEI, and R. CHINIPARDAZ, “EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. -, no. 35, pp. 41–49, 2003, [Online]. Available: https://sid.ir/paper/12813/en

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