THE EFFECT OF AMPICILLIN AND GENTAMCIN CONJUGATED WITH GOLD NANOPARTICLES ON THE FORMATION OF BIOFILMS IN PSEUDOMONAS AERUGINOSA

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JAVADI ALI; ROSTAMI RAD MEHDI; ZAND MONFARED MOHAMMAD REZA; DASTJANI FARAHANI FARIBA; HEIDARPOUR AZAM; KHODADAD MOTLAGH MOHAMMAD

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2015 | Volume:9 | Issue:5 Page(s): 35-41

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Title

THE EFFECT OF AMPICILLIN AND GENTAMCIN CONJUGATED WITH GOLD NANOPARTICLES ON THE FORMATION OF BIOFILMS IN PSEUDOMONAS AERUGINOSA

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Keywords

PSEUDOMONAS AERUGINOSAQ2

NANOPARTICLESQ1

AMPICILLINQ2

GENTAMICINSQ2

ANTIBIOFILM ACTIVITYQ2

Abstract

Background and Objectives: PSEUDOMONAS AERUGINOSAis a gram-negative bacterium and an opportunistic pathogen with several virulence factors. This bacterium is one of the common pathogens in nosocomial infections, particularly in patients with cystic fibrosis. Also, one of the important mechanisms of the survival of this pathogen in the pulmonary disease is biofilm formation. This study was conducted with the purpose of determining the sub-MIC concentrations of two antibiotics, AMPICILLIN and gentamicin, along with the form conjugated with gold NANOPARTICLES on the formation of biofilms in mucoid strain of PSEUDOMONAS AERUGINOSA.Methods: In this study, gold NANOPARTICLES were synthesized using trisodium citrate in a chemical reduction method, then the shape and size of gold NANOPARTICLES were determined by transmission electron microscopy (TEM).Conjugation of gold NANOPARTICLES with AMPICILLIN and gentamicin antibiotics was performed by mixing them together. To test the effect of compound son biofilm formation, micro plate method was performed.Results: In this study, approximate size of NANOPARTICLES was determined to be 10nm. In electronic image (in conjugated form), accumulation of NANOPARTICLES was observed in the image. Also, gold NANOPARTICLES conjugated with the drugs, had better effect on biofilm formation compared to free form of the drugs.Conclusion: According to the results of this study, gold NANOPARTICLES by increasing the concentration of drug around themselves result in better inhibitory effect of drug on the biofilm formation compared to the free form of drug.

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APA: Copy

JAVADI, ALI, ROSTAMI RAD, MEHDI, ZAND MONFARED, MOHAMMAD REZA, DASTJANI FARAHANI, FARIBA, HEIDARPOUR, AZAM, & KHODADAD MOTLAGH, MOHAMMAD. (2015). THE EFFECT OF AMPICILLIN AND GENTAMCIN CONJUGATED WITH GOLD NANOPARTICLES ON THE FORMATION OF BIOFILMS IN PSEUDOMONAS AERUGINOSA. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 9(5), 35-41. SID. https://sid.ir/paper/132343/en

Vancouver: Copy

JAVADI ALI, ROSTAMI RAD MEHDI, ZAND MONFARED MOHAMMAD REZA, DASTJANI FARAHANI FARIBA, HEIDARPOUR AZAM, KHODADAD MOTLAGH MOHAMMAD. THE EFFECT OF AMPICILLIN AND GENTAMCIN CONJUGATED WITH GOLD NANOPARTICLES ON THE FORMATION OF BIOFILMS IN PSEUDOMONAS AERUGINOSA. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2015;9(5):35-41. Available from: https://sid.ir/paper/132343/en

IEEE: Copy

ALI JAVADI, MEHDI ROSTAMI RAD, MOHAMMAD REZA ZAND MONFARED, FARIBA DASTJANI FARAHANI, AZAM HEIDARPOUR, and MOHAMMAD KHODADAD MOTLAGH, “THE EFFECT OF AMPICILLIN AND GENTAMCIN CONJUGATED WITH GOLD NANOPARTICLES ON THE FORMATION OF BIOFILMS IN PSEUDOMONAS AERUGINOSA,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 9, no. 5, pp. 35–41, 2015, [Online]. Available: https://sid.ir/paper/132343/en

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