MOLECULAR STUDY OF EXTENDED-SPECTRUM BETA-LACTAMASE (SHV TYPE) IN ESHERICHIA COLI AND KLEBSIELLA PNEUMONIAE ISOLATED FROM MEDICAL CENTERS OF TABRIZ

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MOBASHER KARE JEDI A.R.; NAHAEI M.R.; MOBIN H.; POURNOUR M.; SADEGHI JAVID

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2009 | Volume:2 | Issue:3-4 Page(s): 9-17

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Title

MOLECULAR STUDY OF EXTENDED-SPECTRUM BETA-LACTAMASE (SHV TYPE) IN ESHERICHIA COLI AND KLEBSIELLA PNEUMONIAE ISOLATED FROM MEDICAL CENTERS OF TABRIZ

Author(s)

Keywords

EXTENDED-SPECTRUM BETA-LACTAMASEQ4

ESCHERICHIA COLIQ3

K. PNEUMONIAEQ4

POLYMRASE CHAIN REACTIONQ3

BLASHV GENEQ4

Abstract

Background and objectives: Nowadays, there is an emerging increase in drug resistance in medical centers due to extended use of third generation cephalosporins. This study was conducted to evaluate antibiotic sensitivity profiles of Esherichia coli and Klebsiella pneumoniae isolates collected from four medical centers (Imam Khomeini, Sina, Shohada and Pediatrics) in Tabriz and and detection of presence of BLASHV GENE among the isolates.Materials and methods: In total 41 isolates of ESCHERICHIA COLI and 47 isolates of Klebseilla pneumonia were collected from medical centers. The antibiotic sensitivity pattern of the isolated was determined by using drug susceptibility test according to Kirby-Bauer method. Combined disk test was also used as confirmatory test, and the findings were adapted with CLSI standard, PCR technique was used for investigation of presence BLASHV GENE in final step.Results: Among the E. coli and K. PNEUMONIAE isolates, 33 (80.49%) and 43 (91.48%) were resistant to ceftazidime and 32(78.05%) and 42 (89.36%) were resistant to cefotaxime respectively. Forthy out of 41 E. coli isolates (97.5%) were ESBL producers, which among them 7 isolates (17.0%) contained BLASHV GENE. Among 47 K. PNEUMONIAE isolates, 46 (97.8%) were ESBL producers which 12 isolates (25.5%) contained BLASHV GENE. All of the E. coli and K. PNEUMONIAE isolates were sensitive to imipenem.Conclusion: The high resistance profiles encountered in E. coli and K. PNEUMONIAE isolates underlines need for accurate sensitivity testing and also avoidance from inappropriate use of antibiotics in management of ESBL producing bacteria is recommended.

Cites

PREVALENCE OF SHV/CTX-M/TEM (ESBL) BETA-LACTAMASE RESISTANCE GENES IN ESCHERICHIA COLI ISOLATED FROM URINARY TRACT INFECTIONS IN TEHRAN, IRAN

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APA: Copy

MOBASHER KARE JEDI, A.R., NAHAEI, M.R., MOBIN, H., POURNOUR, M., & SADEGHI, JAVID. (2009). MOLECULAR STUDY OF EXTENDED-SPECTRUM BETA-LACTAMASE (SHV TYPE) IN ESHERICHIA COLI AND KLEBSIELLA PNEUMONIAE ISOLATED FROM MEDICAL CENTERS OF TABRIZ. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2(3-4), 9-17. SID. https://sid.ir/paper/132595/en

Vancouver: Copy

MOBASHER KARE JEDI A.R., NAHAEI M.R., MOBIN H., POURNOUR M., SADEGHI JAVID. MOLECULAR STUDY OF EXTENDED-SPECTRUM BETA-LACTAMASE (SHV TYPE) IN ESHERICHIA COLI AND KLEBSIELLA PNEUMONIAE ISOLATED FROM MEDICAL CENTERS OF TABRIZ. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2009;2(3-4):9-17. Available from: https://sid.ir/paper/132595/en

IEEE: Copy

A.R. MOBASHER KARE JEDI, M.R. NAHAEI, H. MOBIN, M. POURNOUR, and JAVID SADEGHI, “MOLECULAR STUDY OF EXTENDED-SPECTRUM BETA-LACTAMASE (SHV TYPE) IN ESHERICHIA COLI AND KLEBSIELLA PNEUMONIAE ISOLATED FROM MEDICAL CENTERS OF TABRIZ,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 2, no. 3-4, pp. 9–17, 2009, [Online]. Available: https://sid.ir/paper/132595/en

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