STUDY OF ESTROGEN RECEPTOR-α A908G (K303R) MUTATION WITH BREAST CANCER RISK

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ABBASI SAKINEH; YARIPOUR HOSSEIN; RASOULI MINA

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Journal: Iranian Journal of Breast Diseases Year:2014 | Volume:7 | Issue:3 Page(s): 30-42

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Title

STUDY OF ESTROGEN RECEPTOR-α A908G (K303R) MUTATION WITH BREAST CANCER RISK

Author(s)

ABBASI SAKINEH | YARIPOUR HOSSEIN | RASOULI MINA | Issue Writer Certificate

Keywords

BREAST CANCERQ2

MUTATIONQ3

ESTROGEN RECEPTORQ3

PCR-SSCPQ3

LYMPH NODE METASTASISQ3

Abstract

Background: Genetic MUTATIONs in premalignant breast lesions may have a role in malignancy progression or influence the behavior of subsequent disease. A point MUTATION in ESTROGEN RECEPTOR-a (ESR1) as A908G (Lys303®Arg) was originally involved to hypersensitive to estrogen breast hyperplasia. We detected this MUTATION among Iranian women with invasive BREAST CANCER.Methods: A population-based case-control study was conducted in 150 newly diagnosed invasive BREAST CANCER and 147 healthy control individuals to screen for presence of the ESR1 A908G MUTATION by using single-strand conformation polymorphism (SSCP) analysis and 33Pcycle DNA sequencing.Results: We detected the 10.7% ESR1 A908G MUTATION in the form of heterozygote genotype only among cancer patients (P=0.00). The allelic frequency of mutant allele AGG in codon 303 was significantly (P=0.001) higher in patients with the family history of BREAST CANCER (28.9%) than those without the family history of BREAST CANCER (1.9%).Conclusion: Our data suggest that ESR1 codon 303 MUTATIONs are correlated with various aspects of BREAST CANCER in Iran. ER-α genotype might represent a surrogate marker for predicting BREAST CANCER developing later in life.

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APA: Copy

ABBASI, SAKINEH, YARIPOUR, HOSSEIN, & RASOULI, MINA. (2014). STUDY OF ESTROGEN RECEPTOR-α A908G (K303R) MUTATION WITH BREAST CANCER RISK. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 7(3), 30-42. SID. https://sid.ir/paper/144604/en

Vancouver: Copy

ABBASI SAKINEH, YARIPOUR HOSSEIN, RASOULI MINA. STUDY OF ESTROGEN RECEPTOR-α A908G (K303R) MUTATION WITH BREAST CANCER RISK. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2014;7(3):30-42. Available from: https://sid.ir/paper/144604/en

IEEE: Copy

SAKINEH ABBASI, HOSSEIN YARIPOUR, and MINA RASOULI, “STUDY OF ESTROGEN RECEPTOR-α A908G (K303R) MUTATION WITH BREAST CANCER RISK,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 7, no. 3, pp. 30–42, 2014, [Online]. Available: https://sid.ir/paper/144604/en

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