CORRELATION OF HISTOLOGICAL PREDICTIVE FACTOR IN BREAST CANCER (ER, PR, P53, HER-2) WITH AGE AND MENOPAUSAL STATUS

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SIRATI F.; GHAHARI A.; ALAVI N.

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Journal: Iranian Journal of Breast Diseases Year:2009 | Volume:1 | Issue:3 (3) Page(s): 24-31

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Title

CORRELATION OF HISTOLOGICAL PREDICTIVE FACTOR IN BREAST CANCER (ER, PR, P53, HER-2) WITH AGE AND MENOPAUSAL STATUS

Author(s)

SIRATI F. | GHAHARI A. | ALAVI N. | Issue Writer Certificate

Keywords

PROGNOSTIC FACTORSQ2

BREAST CANCERQ3

AGEQ3

MENOPAUSEQ4

ERQ4

PRQ4

HER2Q4

Abstract

Background: BREAST CANCER is the major cause of death in 40-44 years old females and is the most common site specific cancer in them. Some of PROGNOSTIC FACTORS are tumor size, pathologic grade, auxiliary lymph nodes, ER, PR, P53 and HER-2-neu that are effective in PRognosis and therapeutic plan. Frequency and relationship of the last four markers with each other and with MENOPAUSE and AGE are discussed in this article.Material and methods: 200 female patients with pathology documented ductal or lobular BREAST CANCER were studied in a 3 years period by IHC method for ER, PR, P53 and HER-2-neu.All the patients were female mean AGE of 49.6 years (ED=+ 11.36) from 26-81 years old.Results: ER was positive in 142 cases (71%), PR was positive in 131 cases (65.5%), P53 was positive in 63 cases (31.5%), and HER-2-neu was positive in 143 cases (71.5%).There was a significant positive correlation between ER and PR (P<0.05).there was a significant negative correlation between P53 and ER or PR. There was a significant positive correlation only between ER and AGE.There werenot any correlation between each marker and MENOPAUSE.HER-2-neu indicates the worst PRognosis and better response to chemotherapy. There was a significant difference of HER-2-neu in the reference texts (25%- 37%) and this research (71.5%), which may be caused by genetic differences.Conclusion: there is some differences between Iranian and other patients in PROGNOSTIC FACTORS, so we must consider these differences for diagnosis, treatment and fallow up of BREAST CANCER patients in Iran.

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References

THE ROLE OF HER- 2 IN PROGNOSIS AND TREATMENT OF BREAST CANCER ARTICLE REVIEW

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APA: Copy

SIRATI, F., GHAHARI, A., & ALAVI, N.. (2009). CORRELATION OF HISTOLOGICAL PREDICTIVE FACTOR IN BREAST CANCER (ER, PR, P53, HER-2) WITH AGE AND MENOPAUSAL STATUS. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 1(3 (3)), 24-31. SID. https://sid.ir/paper/144634/en

Vancouver: Copy

SIRATI F., GHAHARI A., ALAVI N.. CORRELATION OF HISTOLOGICAL PREDICTIVE FACTOR IN BREAST CANCER (ER, PR, P53, HER-2) WITH AGE AND MENOPAUSAL STATUS. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2009;1(3 (3)):24-31. Available from: https://sid.ir/paper/144634/en

IEEE: Copy

F. SIRATI, A. GHAHARI, and N. ALAVI, “CORRELATION OF HISTOLOGICAL PREDICTIVE FACTOR IN BREAST CANCER (ER, PR, P53, HER-2) WITH AGE AND MENOPAUSAL STATUS,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 1, no. 3 (3), pp. 24–31, 2009, [Online]. Available: https://sid.ir/paper/144634/en

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