THE EFFECT OF COMBINED VITAMIN SUPPLEMENTS COMPARED WITH SINGLE VITAMINS D3, A, E IN REDUCING OXIDATIVE STRESS IN FEMALE MICE WITH BREAST CANCER

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NABATCHIAN FARIBA; ASHTEEANI MOJTABA; NOROOZI ALI

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Journal: Payavard Salamat Year:2016 | Volume:10 | Issue:2 Page(s): 119-132

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Title

THE EFFECT OF COMBINED VITAMIN SUPPLEMENTS COMPARED WITH SINGLE VITAMINS D3, A, E IN REDUCING OXIDATIVE STRESS IN FEMALE MICE WITH BREAST CANCER

Author(s)

NABATCHIAN FARIBA | ASHTEEANI MOJTABA | NOROOZI ALI | Issue Writer Certificate

Keywords

VITAMIN SUPPLEMENTSQ2

OXIDATIVE STRESSQ1

BREAST CANCERQ1

Abstract

Background and Aim: BREAST CANCER is epidemiological and most important cause of death in women. OXIDATIVE STRESS plays an important role in this disease. Antioxidants such as some vitamins has attracted the attention of scientists to deal with OXIDATIVE STRESS. The aim of this study was to determine the effect of VITAMIN SUPPLEMENTS in reducing OXIDATIVE STRESS in BREAST CANCER.Materials and Methods: 38 BALB-C mice were used. They were created in the BREAST CANCER by cell implantation procedure. Rats were divided into 4 groups: 4 mice were given VITAMIN SUPPLEMENTS for 1 month, 4 mice vitamin A, 4 mice, vitamin D, and 4 mice were given vitamin E respectively. After a month mice had BREAST CANCER. In the second group mice without VITAMIN SUPPLEMENTS, were affected. In the third group, mice with VITAMIN SUPPLEMENTS were not affected. In the blood serum of rats, the catalase, superoxide dismutase and total antioxidant capacity was measured by ELISA.Results: Catalase activity in mice that received VITAMIN SUPPLEMENTS was significantly increased and were diagnosed (P=0.049). But the increase was not significant with vitamin D supplement (P=0.287). Superoxide dismutase in mice that received VITAMIN SUPPLEMENTS and were free of disease increased significantly (P=0.0249). But the increase was not statistically significant with vitamin D supplement (P=0.24).The total antioxidant capacity in mice that received VITAMIN SUPPLEMENTS and were affected with BREAST CANCER was significantly increased (P<0.0001). This increase was not significant with vitamin D (P=0.006).Conclusion: The use of VITAMIN SUPPLEMENTS with catalase, superoxide dismutase and total antioxidant capacity was significantly correlated and may increase the level of antioxidant markers.

Cites

THE EFFECT OF DIFFERENT DOSES OF ALCOHOLIC EXTRACT OF ALFALFA ON THE CONTROL OF OXIDATIVE STRESS BY NICOTINE IN THE OVARIES OF FEMALE RATS

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APA: Copy

NABATCHIAN, FARIBA, ASHTEEANI, MOJTABA, & NOROOZI, ALI. (2016). THE EFFECT OF COMBINED VITAMIN SUPPLEMENTS COMPARED WITH SINGLE VITAMINS D3, A, E IN REDUCING OXIDATIVE STRESS IN FEMALE MICE WITH BREAST CANCER. PAYAVARD-SALAMAT, 10(2 ), 119-132. SID. https://sid.ir/paper/149635/en

Vancouver: Copy

NABATCHIAN FARIBA, ASHTEEANI MOJTABA, NOROOZI ALI. THE EFFECT OF COMBINED VITAMIN SUPPLEMENTS COMPARED WITH SINGLE VITAMINS D3, A, E IN REDUCING OXIDATIVE STRESS IN FEMALE MICE WITH BREAST CANCER. PAYAVARD-SALAMAT[Internet]. 2016;10(2 ):119-132. Available from: https://sid.ir/paper/149635/en

IEEE: Copy

FARIBA NABATCHIAN, MOJTABA ASHTEEANI, and ALI NOROOZI, “THE EFFECT OF COMBINED VITAMIN SUPPLEMENTS COMPARED WITH SINGLE VITAMINS D3, A, E IN REDUCING OXIDATIVE STRESS IN FEMALE MICE WITH BREAST CANCER,” PAYAVARD-SALAMAT, vol. 10, no. 2 , pp. 119–132, 2016, [Online]. Available: https://sid.ir/paper/149635/en

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