EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF ALCOHOLIC EXTRACT OF HAWTHORN (CRATAEGUS MELANO CARPA) LEAVES ON FEAR BEHAVIOR IN PRESENCE PENTYLENETETRAZOLE (PTZ) IN ADULT MALE RAT

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DARABI P.; TAVAKOLI FAR B.; VAEZI GH.; KERAMATI K.

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Journal: Journal of Medicinal Plants Year:2012 | Volume:11 | Issue:44 Page(s): 202-211

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Title

EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF ALCOHOLIC EXTRACT OF HAWTHORN (CRATAEGUS MELANO CARPA) LEAVES ON FEAR BEHAVIOR IN PRESENCE PENTYLENETETRAZOLE (PTZ) IN ADULT MALE RAT

Author(s)

DARABI P. | TAVAKOLI FAR B. | VAEZI GH. | KERAMATI K. | Issue Writer Certificate

Keywords

CRATAEGUS MELANOCARPAQ2

PENTYLENETETRAZOLEQ3

MEMORY AND LEARNINGQ3

FEARQ2

Abstract

Background: In traditional medicine "CRATAEGUS MELANOCARPA" is one of the medicinal plants that has many therapeutic effects. One of them is its effect on nerveous system.Objective: Evaluation of Intracerebroventricular (ICV) injection of alcoholic extract of "CRATAEGUS MELANOCARPA" leaves on FEAR behavior in presence PENTYLENETETRAZOLE (PTZ) in adult male rat.Methods: Animals were divided into 3 groups: experimental, saline and, PENTYLENETETRAZOLE (PTZ) 20mg/kg as positive control (I.P). In the experimental group, the animals received 4000mg/Rat alcoholic extract of "CRATAEGUS MELANOCARPA" leaves (ICV) and PTZ (I.P). Then plus maze was used for evaluation of the FEAR. Open arm entries percentage (%OAE) and open arm time percentage (%OAT) were evaluated.Results: The results show that intracerebroventricular (ICV) injection of alcoholic extract of "CRATAEGUS MELANOCARPA" leaves increased %OAE and %OAT significantly (p<0.05).Conclusion: We concluded that alcoholic extract of "CRATAEGUS MELANOCARPA" is effective on FEAR reduction in presence PENTYLENETETRAZOLE (PTZ) in adult male rat.

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APA: Copy

DARABI, P., TAVAKOLI FAR, B., VAEZI, GH., & KERAMATI, K.. (2012). EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF ALCOHOLIC EXTRACT OF HAWTHORN (CRATAEGUS MELANO CARPA) LEAVES ON FEAR BEHAVIOR IN PRESENCE PENTYLENETETRAZOLE (PTZ) IN ADULT MALE RAT. JOURNAL OF MEDICINAL PLANTS, 11(44), 202-211. SID. https://sid.ir/paper/15182/en

Vancouver: Copy

DARABI P., TAVAKOLI FAR B., VAEZI GH., KERAMATI K.. EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF ALCOHOLIC EXTRACT OF HAWTHORN (CRATAEGUS MELANO CARPA) LEAVES ON FEAR BEHAVIOR IN PRESENCE PENTYLENETETRAZOLE (PTZ) IN ADULT MALE RAT. JOURNAL OF MEDICINAL PLANTS[Internet]. 2012;11(44):202-211. Available from: https://sid.ir/paper/15182/en

IEEE: Copy

P. DARABI, B. TAVAKOLI FAR, GH. VAEZI, and K. KERAMATI, “EFFECTS OF INTRACEREBROVENTRICULAR INJECTION OF ALCOHOLIC EXTRACT OF HAWTHORN (CRATAEGUS MELANO CARPA) LEAVES ON FEAR BEHAVIOR IN PRESENCE PENTYLENETETRAZOLE (PTZ) IN ADULT MALE RAT,” JOURNAL OF MEDICINAL PLANTS, vol. 11, no. 44, pp. 202–211, 2012, [Online]. Available: https://sid.ir/paper/15182/en

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