NEUROPROTECTIVE EFFECT OF AQUEOUS EXTRACT OF BERBERIS VULGARIS L. IN A MODEL OF PARKINSON’S DISEASE IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SALAR FARIBA; ZIAEI S.A.; NASRI SIMA; ROGHANI MEHRDAD; KAMALINEZHAD MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2010 | Volume:9 | Issue:36 Page(s): 24-33

Download Full-Text

Persian Verion

View:

1,376

Download:

Cites:

Information Journal Paper

Title

NEUROPROTECTIVE EFFECT OF AQUEOUS EXTRACT OF BERBERIS VULGARIS L. IN A MODEL OF PARKINSON’S DISEASE IN RAT

Author(s)

Keywords

BERBERIS VULGARISQ3

PARKINSON’S DISEASEQ3

6-OHDAQ3

ANGIOTENSIN CONVERTING ENZYMEQ3

Abstract

Background: PARKINSON’S DISEASE is a neurodegenerative disease of dopaminergic neurons in substancia nigra. Superoxides formation is one of the main etiologies of the disease, and ANGIOTENSIN CONVERTING ENZYME inhibitors (ACEIs) are able to suppress superoxide formation. Objective: BERBERIS VULGARIS is an ACE inhibitor and considered for this purpose.Methods: Male rats (n=32) were divided in 4 groups: Sham, Neurotoxin (injection of 6-hydroxydopamine into left hemisphere SNC), BERBERIS VULGARIS aqueous extract (10 mg/kg) and captopril. Berberis and captopril were injected i.p. 7 days before and 3 days after 6-hydroxydopamine injection. Muscle rigidity, apomorphine test, brain protein oxidation and lipid peroxidation as well as serum and brain ACE activity were assayed in all 4 groups.Results: Rotation test with apomorphine in captopril and Berberis groups were significantly lower than neurotoxin group (p=0.002). Lipid peroxidation in captopril was significantly lower than neurotoxin (p=0.013). Captopril and Berberis both inhibited serum ACE activity respectively, but Berberis inhibited brain ACE too.Conclusion: BERBERIS VULGARIS aqueous extract is an ACE inhibitor with anti-parkinsonism effect and should be studied more.

Cites

No record.

References

Cite

APA: Copy

SALAR, FARIBA, ZIAEI, S.A., NASRI, SIMA, ROGHANI, MEHRDAD, & KAMALINEZHAD, MOHAMMAD. (2010). NEUROPROTECTIVE EFFECT OF AQUEOUS EXTRACT OF BERBERIS VULGARIS L. IN A MODEL OF PARKINSON’S DISEASE IN RAT. JOURNAL OF MEDICINAL PLANTS, 9(36), 24-33. SID. https://sid.ir/paper/15343/en

Vancouver: Copy

SALAR FARIBA, ZIAEI S.A., NASRI SIMA, ROGHANI MEHRDAD, KAMALINEZHAD MOHAMMAD. NEUROPROTECTIVE EFFECT OF AQUEOUS EXTRACT OF BERBERIS VULGARIS L. IN A MODEL OF PARKINSON’S DISEASE IN RAT. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(36):24-33. Available from: https://sid.ir/paper/15343/en

IEEE: Copy

FARIBA SALAR, S.A. ZIAEI, SIMA NASRI, MEHRDAD ROGHANI, and MOHAMMAD KAMALINEZHAD, “NEUROPROTECTIVE EFFECT OF AQUEOUS EXTRACT OF BERBERIS VULGARIS L. IN A MODEL OF PARKINSON’S DISEASE IN RAT,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. 36, pp. 24–33, 2010, [Online]. Available: https://sid.ir/paper/15343/en

Related Journal Papers