Cryptosporidium and Microsporidia Infections in Children with Cancer: Epidemiology, Diagnosis and Treatment Strategies

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Makipour Hanieh; Mirjalali Hamed; Salehi Kahyesh Roya

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF ENTERIC PATHOGENS Year:2024 | Volume:12 | Issue:3 Page(s): 129-135

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Cryptosporidium and Microsporidia Infections in Children with Cancer: Epidemiology, Diagnosis and Treatment Strategies

Author(s)

Makipour Hanieh | Mirjalali Hamed | Salehi Kahyesh Roya | Issue Writer Certificate

Keywords

Cryptosporidium

Microsporidia

Diagnosis

Children

Cancer

Abstract

Cryptosporidium spp. and Microsporidia spp., intracellular protozoan parasites, represent significant etiologic agents of opportunistic infections in immunocompromised pediatric cancer patients. These pathogens cause severe gastrointestinal symptoms including persistent diarrhea, abdominal pain, and weight loss which may be fatal in advanced stages. In developing countries with suboptimal sanitation, co-infections exacerbate morbidity among children with cancer. With the global incidence of childhood cancer increasing, immunosuppressive chemotherapy markedly heightens susceptibility to these infections. This review evaluates their epidemiology, clinical manifestations, diagnostic methodologies, and the pivotal role of early detection. The severity of infections hinges on immune competence, nutritional status, and parasite species. Although self-limiting in immunocompetent hosts, these infections persist in immunocompromised children, precipitating dehydration, malnutrition, and delays in cancer therapy. Early diagnosis is imperative to mitigate complications and enhance outcomes through prompt supportive care and infection control measures. Diagnostic techniques, such as modified acid-fast staining for Cryptosporidium spp., modified trichrome staining for Microsporidia spp., and polymerase chain reaction (PCR), exhibit variable sensitivity; however, challenges in consistent detection and therapeutic resistance persist, particularly in resource-constrained settings. In such regions, low-cost diagnostics frequently fail to detect low burden infections, and treatment options beyond rehydration and nutritional support remain limited. Advances in molecular epidemiology have deepened insights into these infections, yet practical obstacles endure in pediatric oncology. Future investigations should prioritize the development of accessible high precision diagnostics such as next generation sequencing and targeted therapeutic strategies to reduce morbidity and improve survival and quality of life in this vulnerable cohort.

Multimedia

No record.

Cites

No record.

References