STUDY OF SALVIA OFFICINALIS HYDROETHANOLIC EXTRACT ON SERUM THYROID HORMONE LEVELS IN HYPOTHYROID MALE RAT

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MIRAZI N.; ABDOLMALEKI N.; MAHMOODI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Avicenna Journal of Clinical Medicine Year:2013 | Volume:19 | Issue:4 (SN 66) Page(s): 27-35

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Title

STUDY OF SALVIA OFFICINALIS HYDROETHANOLIC EXTRACT ON SERUM THYROID HORMONE LEVELS IN HYPOTHYROID MALE RAT

Author(s)

MIRAZI N. | ABDOLMALEKI N. | MAHMOODI M. | Issue Writer Certificate

Keywords

HYPOTHYROIDISMQ2

LEVOTHYROXINEQ2

PROPYLTHIOURACILQ2

RATSQ2

SALVIA OFFICINALISQ2

Abstract

Introduction & Objective: Medicinal plants are widely used throughout the world. HYPOTHYROIDISM is an important hormonal disease that causes some disorders in body organs. SALVIA OFFICINALIS has been known as a medicinal plant since ancient times. In this study the SALVIA OFFICINALIS extract (SOE) effects on thyroid hormones and TSH in hypothyroid RATS have been investigated.Materials & Methods: In this experimental study the SOE extract was prepared and 40 male RATS were randomly divided in five groups. Control, PROPYLTHIOURACIL (PTU) in 4 groups+SOE. The animals were induced HYPOTHYROIDISM by administration of PTU 0.1% orally in tap water for 14 days. The blood samples were collected and T3 & T4 and TSH hormones were analyzed. Hypothyroid groups were divided into 4 groups and received (PTU+SOE 40 mg/kg+levothyroxine sodium, 15mcg/kg, orally in tap water) and LV+SOE). All test groups were treated with SOE and LEVOTHYROXINE sodium for one week. The blood samples were collected and for T3 & T4 and TSH hormones were analyzed at the end of the 3rd week. All data were expressed as mean±SEM and all statistical procedures were performed by MANOVA test.Results: Our results showed that the T3 & T4 plasma levels in hypothyroid animals treated by SOE had significant differences (P<0.05) compared with the control group.Conclusion: Our findings suggest that the SOE has stimulatory effect on thyroid gland function and raises plasma T3 & T4 levels.

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APA: Copy

MIRAZI, N., ABDOLMALEKI, N., & MAHMOODI, M.. (2013). STUDY OF SALVIA OFFICINALIS HYDROETHANOLIC EXTRACT ON SERUM THYROID HORMONE LEVELS IN HYPOTHYROID MALE RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), 19(4 (SN 66)), 27-35. SID. https://sid.ir/paper/17259/en

Vancouver: Copy

MIRAZI N., ABDOLMALEKI N., MAHMOODI M.. STUDY OF SALVIA OFFICINALIS HYDROETHANOLIC EXTRACT ON SERUM THYROID HORMONE LEVELS IN HYPOTHYROID MALE RAT. AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)[Internet]. 2013;19(4 (SN 66)):27-35. Available from: https://sid.ir/paper/17259/en

IEEE: Copy

N. MIRAZI, N. ABDOLMALEKI, and M. MAHMOODI, “STUDY OF SALVIA OFFICINALIS HYDROETHANOLIC EXTRACT ON SERUM THYROID HORMONE LEVELS IN HYPOTHYROID MALE RAT,” AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES), vol. 19, no. 4 (SN 66), pp. 27–35, 2013, [Online]. Available: https://sid.ir/paper/17259/en

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