THE LONG-TERM RESULTS OF TRANSSTERNAL THYMECTOMY AND ITS RELATED FACTORS IN PATIENTS WITH MYASTHENIA GRAVIS PRESENTING AT LOGHMAN HAKIM HOSPITAL IN TEHRAN DURING 1993- 2007: A DESCRIPTIVE STUDY

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HAJI NASRELAH E.; KHOUSHKAR A.; MOUSAVIAN S.A.; SALEHI N.A.; PEYVANDI H.; ARAYESHKHAH M.

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Journal: Researcher Bulletin of Medical Sciences Year:2010 | Volume:14 | Issue:6 (72) Page(s): 313-317

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Title

THE LONG-TERM RESULTS OF TRANSSTERNAL THYMECTOMY AND ITS RELATED FACTORS IN PATIENTS WITH MYASTHENIA GRAVIS PRESENTING AT LOGHMAN HAKIM HOSPITAL IN TEHRAN DURING 1993- 2007: A DESCRIPTIVE STUDY

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Keywords

MYASTHENIA GRAVISQ3

THYMECTOMEYQ3

THYMUS GLANDQ3

Abstract

Background & Aim: MYASTHENIA GRAVIS is an autoimmune disease characterized by production of autoantibody directly against acetylcholine receptors on post-junctional membranes. The complete removal of the thymus has been the logical goal of operation, but there has been controversy on its relation to long term results. In this study, we try to describe the efficacy of long term result of transsternal thymectomy, and the rate of improvement in patients with MYASTHENIA GRAVIS that presented to Loghman Hakim Hospital, in Tehran, between 1993 and 2007. Materials & Methods: The study descriptively analyzed all patients with general MYASTHENIA GRAVIS with transsternal thymectomy. At first all patients with MYASTHENIA GRAVIS on the study year’s period were found and invited. Efficacy of surgery was studied with dosage of used drug, signs, age, sex, thymus pathology, etc. and was statistically expressed. A maximum of 15 years of post-surgery follow-up was studied (Mean= 9 yrs). Results: In study years, 63 patients underwent thymectomy, 48 of whom met the criteria to enroll in our study (76.2%). Overall, surgical benefit after thymectomy was 77% and 31.2% of the patients were completely cured. In 45.8% of the patients, drug doses were reduced. In 18.7% of the patients drug dose had not changed. In 4.2 % of patients, the disease had progressed. Most of the improvement was seen in the first 2 years post- thymectomy. Conclusion: Thymectomy is a beneficial treatment modality in patients with generalized MYASTHENIA GRAVIS. The efficacy of transsternal thymectomy for MYASTHENIA GRAVIS had satisfactory results by examining and long-term follow-up of patients. But further investigation in mass population in clinical trials is needed.

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APA: Copy

HAJI NASRELAH, E., KHOUSHKAR, A., MOUSAVIAN, S.A., SALEHI, N.A., PEYVANDI, H., & ARAYESHKHAH, M.. (2010). THE LONG-TERM RESULTS OF TRANSSTERNAL THYMECTOMY AND ITS RELATED FACTORS IN PATIENTS WITH MYASTHENIA GRAVIS PRESENTING AT LOGHMAN HAKIM HOSPITAL IN TEHRAN DURING 1993- 2007: A DESCRIPTIVE STUDY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 14(6 (72)), 313-317. SID. https://sid.ir/paper/18526/en

Vancouver: Copy

HAJI NASRELAH E., KHOUSHKAR A., MOUSAVIAN S.A., SALEHI N.A., PEYVANDI H., ARAYESHKHAH M.. THE LONG-TERM RESULTS OF TRANSSTERNAL THYMECTOMY AND ITS RELATED FACTORS IN PATIENTS WITH MYASTHENIA GRAVIS PRESENTING AT LOGHMAN HAKIM HOSPITAL IN TEHRAN DURING 1993- 2007: A DESCRIPTIVE STUDY. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2010;14(6 (72)):313-317. Available from: https://sid.ir/paper/18526/en

IEEE: Copy

E. HAJI NASRELAH, A. KHOUSHKAR, S.A. MOUSAVIAN, N.A. SALEHI, H. PEYVANDI, and M. ARAYESHKHAH, “THE LONG-TERM RESULTS OF TRANSSTERNAL THYMECTOMY AND ITS RELATED FACTORS IN PATIENTS WITH MYASTHENIA GRAVIS PRESENTING AT LOGHMAN HAKIM HOSPITAL IN TEHRAN DURING 1993- 2007: A DESCRIPTIVE STUDY,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 14, no. 6 (72), pp. 313–317, 2010, [Online]. Available: https://sid.ir/paper/18526/en

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