THE CLINICAL OUTCOME OF THYMECTOMY IN MYASTHENIA GRAVIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRSHARIFI R.; MOULAVI S.; AMINIAN ALI; KARIMIAN FARAMARZ; HARIRCHIAN M.H.; FAZELI M.S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2009 | Volume:66 | Issue:11 Page(s): 821-825

Download Full-Text

Persian Verion

View:

2,099

Download:

Cites:

Information Journal Paper

Title

THE CLINICAL OUTCOME OF THYMECTOMY IN MYASTHENIA GRAVIS

Author(s)

Keywords

MYASTHENIA GRAVISQ3

THYMOMAQ3

THYMECTOMYQ3

THYMUS GLANDQ3

Abstract

Background: MYASTHENIA GRAVIS (MG) is a neuromuscular disorder with weakness of skeletal muscles. THYMECTOMY is now recognized as a treatment modality in MG. The aim of this study was to evaluate the clinical effect of THYMECTOMY on MG.Methods: MG patients with history of THYMECTOMY at a tertiary referral center during twelve year period were included. The medical records were reviewed and telephone survey was conducted to evaluate the effects of THYMECTOMY.Results: Sixty MG patients, 46 females and 14 males, aged 30.4±11.1 years, underwent open (n=48) or video-assisted thoracoscopic THYMECTOMY (n=12) during study period.The mean dosage of preoperative pyridostigmine was 235.4±86.2mg/day. This figure reached to 129±18mg/day after THYMECTOMY (p<0.0001). 17 patients (28.3%) had complete remission (complete freedom of symptoms without medications). Improvement (improved symptoms or less medication requirement) was seen in 34 patients (56.6%). There was no response to surgical therapy in six patients (10%). Three patients (5%) had experienced progression of disease postoperatively. Overall, benefit of THYMECTOMY was observed in 85% of patients. Age, sex, duration and severity of disease, quantity of preoperative drugs, surgical approach, and presence of THYMOMA did not affect the outcome. Satisfaction was stated as excellent in 17%, good in 43%, moderate in 35% and poor in 5% of patients after operation.Conclusion: THYMECTOMY is an effective treatment for MG which leads to less severity of disease and less drug requirement. It would be considered in all myasthenic patients regardless of age, sex, duration and severity of disease and presence of THYMOMA.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRSHARIFI, R., MOULAVI, S., AMINIAN, ALI, KARIMIAN, FARAMARZ, HARIRCHIAN, M.H., & FAZELI, M.S.. (2009). THE CLINICAL OUTCOME OF THYMECTOMY IN MYASTHENIA GRAVIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(11), 821-825. SID. https://sid.ir/paper/39462/en

Vancouver: Copy

MIRSHARIFI R., MOULAVI S., AMINIAN ALI, KARIMIAN FARAMARZ, HARIRCHIAN M.H., FAZELI M.S.. THE CLINICAL OUTCOME OF THYMECTOMY IN MYASTHENIA GRAVIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;66(11):821-825. Available from: https://sid.ir/paper/39462/en

IEEE: Copy

R. MIRSHARIFI, S. MOULAVI, ALI AMINIAN, FARAMARZ KARIMIAN, M.H. HARIRCHIAN, and M.S. FAZELI, “THE CLINICAL OUTCOME OF THYMECTOMY IN MYASTHENIA GRAVIS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 11, pp. 821–825, 2009, [Online]. Available: https://sid.ir/paper/39462/en

Related Journal Papers