EFFECT OF COENZYME Q10 (UBIQUINONE) ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING TRANSIENT GLOBAL ISCHEMIA/REPERFUSION IN MALE WISTAR RAT

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HASHEMZADEH ELHAM; MOVASSAGHI SHABNAM; SHAFAROODI HAMED; ASHOORI BARMCHI ALIEH; SHARIFI ZAHRA NADIA

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Journal: JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES Year:2014 | Volume:3 | Issue:1 Page(s): 21-28

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Title

EFFECT OF COENZYME Q10 (UBIQUINONE) ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING TRANSIENT GLOBAL ISCHEMIA/REPERFUSION IN MALE WISTAR RAT

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Keywords

HIPPOCAMPUSQ1

ISCHEMIAQ1

REPERFUSIONQ1

COENZYME Q10Q2

RATQ2

Abstract

Ischemia/Reperfusion (I/R) -induced cerebral injury has been reported as a leading cause of death and long-term disabilities. HIPPOCAMPUS is an area which is more sensitive to be affected by I/R and hypoxic conditions. COENZYME Q10 is a strong antioxidant which plays a role in membrane stabilization. This study aims to investigate the possible role of CoQ10 in ameliorating the histomorphological changes in the hippocampal CA1 pyramidal cells induced by cerebral I/R.Thirty six adult male wistar RATs were divided into six groups, each group consisting of six RATs, including control, ISCHEMIA, vehicle and CoQ10-treated (10, 50, 100 mg/kg). In treatment groups, RATs were orally administered CoQ10 during five days before and three days after I/R. Global cerebral ISCHEMIA was induced by bilateral common carotid arteries occlusion for about 20 minutes, followed by REPERFUSION. H& E and Nissl staining were utilized for some qualitative and quantitative studies. Then the histomorphological changes were measured by Image Tools 2 software.The data analysis showed a significant reduction in the number of CA1 pyramidal cells after I/R; whearas, no significant difference was seen in the number of cells in mentioned region between control and 100 mg/kg CoQ10-treated groups.The findings indicate the neurotrophic properties of CoQ10 and support the beneficial effects of CoQ10 as an adjuvant therapy in patients who have risk factor (s) of ischemic stroke.

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APA: Copy

HASHEMZADEH, ELHAM, MOVASSAGHI, SHABNAM, SHAFAROODI, HAMED, ASHOORI BARMCHI, ALIEH, & SHARIFI, ZAHRA NADIA. (2014). EFFECT OF COENZYME Q10 (UBIQUINONE) ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING TRANSIENT GLOBAL ISCHEMIA/REPERFUSION IN MALE WISTAR RAT. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, 3(1), 21-28. SID. https://sid.ir/paper/188744/en

Vancouver: Copy

HASHEMZADEH ELHAM, MOVASSAGHI SHABNAM, SHAFAROODI HAMED, ASHOORI BARMCHI ALIEH, SHARIFI ZAHRA NADIA. EFFECT OF COENZYME Q10 (UBIQUINONE) ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING TRANSIENT GLOBAL ISCHEMIA/REPERFUSION IN MALE WISTAR RAT. JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES[Internet]. 2014;3(1):21-28. Available from: https://sid.ir/paper/188744/en

IEEE: Copy

ELHAM HASHEMZADEH, SHABNAM MOVASSAGHI, HAMED SHAFAROODI, ALIEH ASHOORI BARMCHI, and ZAHRA NADIA SHARIFI, “EFFECT OF COENZYME Q10 (UBIQUINONE) ON HIPPOCAMPAL CA1 PYRAMIDAL CELLS FOLLOWING TRANSIENT GLOBAL ISCHEMIA/REPERFUSION IN MALE WISTAR RAT,” JOURNAL OF PHARMACEUTICAL & HEALTH SCIENCES, vol. 3, no. 1, pp. 21–28, 2014, [Online]. Available: https://sid.ir/paper/188744/en

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