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Title

EFFECT OF CICHORIUM INTYBUS L. EXTRACTS AND KELUSSIA ODERATASSIMA MOZAFF. ESSENTIAL OIL ON TOXIC OF ORGANOPHOSPHOUROS INSECTICIDES IN RAT

Pages

  31-36

Abstract

 Background & Aim: ORGANOPHOSPHATES are frequently used as insecticides in households, in agricultural areas and veterinary, thus posing a risk for accidental dermal exposure or through inhalation. Acute organophosphate poisoning causes thousands of human mortalities each year in developing countries.Material & Methods: This study carried out to study an antitoxic effect of endemic Iranian MEDICINAL PLANTS agent against organophosphorus on rats. In order, anti-toxic effects of Cichorium intybus L. root ethanol extract and KELUSSIA ODERATASSIMA Mozaff. leaves essential oil on liver and kidney rat. This is an experimental study in 18 Wistar rats were randomly into 6 groups. After 24 hr fasting, normal saline was given to the first group, two and three groups received 200 and 400 mg/kg Cichorium intybus extract, four and five groups received 200 and 400 mg/kg KELUSSIA ODERATASSIMA essential oil and six groups received standard drug (Phenobarbital).Results & Discussion: The histopathological observation indicated that the lowest necrosis in kidney was group received 200 mg/kg KELUSSIA ODERATASSIMA essential oil and highest necrosis in kidney was groups received 200 and 400 mg/kg Cichorium intybus extract and standard drug. The histopathological observation indicated that standard drug and groups received 400 mg/kg Cichorium intybus extract and 200 mg/kg KELUSSIA ODERATASSIMA essential oil may protect liver against acute hepatotoxicity induced by Organophosphate insecticide. Also the highest of increased weight rats revealed group received 200 mg/kg KELUSSIA ODERATASSIMA essential oil.Conclusion: The results show that KELUSSIA ODERATASSIMA essential oil an antitoxic effect against organophosphrus on at.

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References

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APA: Copy

GHASEMI PIRBALOUTI, ABDOLLAH, SHAHVALI, ALI, SAGHAEE, FIROZEH, SHAHRZAD, AZIZI, HAMEDI, BEHZAD, & SHAHGHOLIAN, LOHRASEB. (2010). EFFECT OF CICHORIUM INTYBUS L. EXTRACTS AND KELUSSIA ODERATASSIMA MOZAFF. ESSENTIAL OIL ON TOXIC OF ORGANOPHOSPHOUROS INSECTICIDES IN RAT. JOURNAL OF HERBAL DRUGS, 1(2), 31-36. SID. https://sid.ir/paper/193783/en

Vancouver: Copy

GHASEMI PIRBALOUTI ABDOLLAH, SHAHVALI ALI, SAGHAEE FIROZEH, SHAHRZAD AZIZI, HAMEDI BEHZAD, SHAHGHOLIAN LOHRASEB. EFFECT OF CICHORIUM INTYBUS L. EXTRACTS AND KELUSSIA ODERATASSIMA MOZAFF. ESSENTIAL OIL ON TOXIC OF ORGANOPHOSPHOUROS INSECTICIDES IN RAT. JOURNAL OF HERBAL DRUGS[Internet]. 2010;1(2):31-36. Available from: https://sid.ir/paper/193783/en

IEEE: Copy

ABDOLLAH GHASEMI PIRBALOUTI, ALI SHAHVALI, FIROZEH SAGHAEE, AZIZI SHAHRZAD, BEHZAD HAMEDI, and LOHRASEB SHAHGHOLIAN, “EFFECT OF CICHORIUM INTYBUS L. EXTRACTS AND KELUSSIA ODERATASSIMA MOZAFF. ESSENTIAL OIL ON TOXIC OF ORGANOPHOSPHOUROS INSECTICIDES IN RAT,” JOURNAL OF HERBAL DRUGS, vol. 1, no. 2, pp. 31–36, 2010, [Online]. Available: https://sid.ir/paper/193783/en

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