Association of UCP3 (Uncoupling protein 3) Gene-55C/T Polymorphism and Obesity in A Juvenile Population of Iran

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Mohamad Rezaii h.; KALANTARI M.; MAHMAZI SANAZ

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Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2018 | Volume:8 | Issue:1 Page(s): 594-600

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Information Journal Paper

Title

Association of UCP3 (Uncoupling protein 3) Gene-55C/T Polymorphism and Obesity in A Juvenile Population of Iran

Author(s)

Mohamad Rezaii h. | KALANTARI M. | MAHMAZI SANAZ | Issue Writer Certificate

Keywords

ObesityQ2

UCP3 geneQ1

PolymorphismQ1

PCR-RFLPQ2

Abstract

Background & Objective: UCP3 is a member of uncoupling proteins which plays an important role in energy homeostasis and it might be important in Obesity. C-55T (rs1800849) Polymorphism in promoter of UCP3 can affect the expression level of UCP3. The aim of this study was to analyze the association of UCP3 C-55T Polymorphism and Obesity in a juvenile population of Iran. Material & Methods: peripheral blood sample from 120 obese and 120 normal university students were collected for DNA extraction. Genotyping of C-55T Polymorphism in the UCP3 gene was performed by PCR-RFLP method. Chi-square test was applied to analyze the data at P<0. 05 significance level. Results: The variant T allele was significantly associated with the Obesity risk. The frequency of T allele was 72% in Obese group compared to 40% in normal subjects (P= 0. 000, OR=3. 8 CI 95% 2. 1 – 6. 9). Conclusion: The UCP3 C-55T Polymorphism was associated with higher BMI and can be regarded as a risk factor for the development of Obesity.

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References

ASSOCIATION BETWEEN PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR, UCP3 AND LIPOPROTEIN LIPASE GENE POLYMORPHISMS AND OBESITY IN CHINESE ADOLESCENTS. OBESITY RESEARCH & CLINICAL PRACTICE

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APA: Copy

Mohamad Rezaii, h., KALANTARI, M., & MAHMAZI, SANAZ. (2018). Association of UCP3 (Uncoupling protein 3) Gene-55C/T Polymorphism and Obesity in A Juvenile Population of Iran. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(1 ), 594-600. SID. https://sid.ir/paper/204054/en

Vancouver: Copy

Mohamad Rezaii h., KALANTARI M., MAHMAZI SANAZ. Association of UCP3 (Uncoupling protein 3) Gene-55C/T Polymorphism and Obesity in A Juvenile Population of Iran. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2018;8(1 ):594-600. Available from: https://sid.ir/paper/204054/en

IEEE: Copy

h. Mohamad Rezaii, M. KALANTARI, and SANAZ MAHMAZI, “Association of UCP3 (Uncoupling protein 3) Gene-55C/T Polymorphism and Obesity in A Juvenile Population of Iran,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 1 , pp. 594–600, 2018, [Online]. Available: https://sid.ir/paper/204054/en

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