EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CA1 REGION BY LIDOCAINE ON AMYGDALA KINDLING RATE IN RATS

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MORTAZAVI M.; MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; ALASVAND M.; PALIZVAN M.R.; ROSTAMPOUR VAJARGAH M.

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Journal: Journal of Kerman University of Medical Sciences Year:2002 | Volume:9 | Issue:4 Page(s): 173-183

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Title

EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CA1 REGION BY LIDOCAINE ON AMYGDALA KINDLING RATE IN RATS

Author(s)

Keywords

SEIZURESQ2

CONVULSIONQ3

KINDLINGQ2

HYPOCAMPUSQ2

AMYGDALESQ3

LIDOCAINEQ3

Abstract

In this study the role of CA1 region of dorsal hippocampus on amygdale KINDLING rate was investigated by bilateral micro injection of LIDOCAINE into the hippocampus. 28 rats were divided into four groups. In group 1, animals were implanted only with a tripolar electrode into the amygdala but in groups 2-4, two guide cannulae were also implanted into the CA1 region of the dorsal hippocampus. Two monopolar electrodes were also attatched to the skull as earth and differential. One week after surgery, the threshold stimulus was determined and each animal was stimulated daily by threshold stimulus to be kindled In group 3 and 4, saline or LIDOCAINE 2% (1µlit/2min) was also injected bilaterally into the hippocampus respectively and animals were stimulated 5 min after injection. Obtained results showed that the number of stimulation to receive from stage 4 to stage 5 seizure was significantly increased in group 4. Thus, it may be suggested that CA1 region of the hippocampus plays an important role in late but not early stages of amygdaloidal kindled SEIZURES and amygdale KINDLING rate.

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APA: Copy

MORTAZAVI, M., MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., ALASVAND, M., PALIZVAN, M.R., & ROSTAMPOUR VAJARGAH, M.. (2002). EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CA1 REGION BY LIDOCAINE ON AMYGDALA KINDLING RATE IN RATS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 9(4), 173-183. SID. https://sid.ir/paper/205/en

Vancouver: Copy

MORTAZAVI M., MIRNAJAFIZADEH S.J., FATH ELAHI Y., ALASVAND M., PALIZVAN M.R., ROSTAMPOUR VAJARGAH M.. EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CA1 REGION BY LIDOCAINE ON AMYGDALA KINDLING RATE IN RATS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;9(4):173-183. Available from: https://sid.ir/paper/205/en

IEEE: Copy

M. MORTAZAVI, S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, M. ALASVAND, M.R. PALIZVAN, and M. ROSTAMPOUR VAJARGAH, “EFFECT OF REVERSIBLE INHIBITION OF HIPPOCAMPAL CA1 REGION BY LIDOCAINE ON AMYGDALA KINDLING RATE IN RATS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 4, pp. 173–183, 2002, [Online]. Available: https://sid.ir/paper/205/en

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