EFFECT OF ENDURANCE TRAINING AND METHADONE ABUSE ON INTERFERON-GAMMA AND INTERLEUKIN-17 SERUM LEVELS IN MORPHINE-DEPENDENT RATS DURING WITHDRAWAL SYNDROME

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HEIDARIANPOUR ALI; VAHIDIAN REZAZADEH MAJID; ZAMANI ALIREZA

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Journal: SPORT AND BIOMOTOR SCIENCES Year:2014 | Volume:6 | Issue:1 (11) Page(s): 58-68

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Title

EFFECT OF ENDURANCE TRAINING AND METHADONE ABUSE ON INTERFERON-GAMMA AND INTERLEUKIN-17 SERUM LEVELS IN MORPHINE-DEPENDENT RATS DURING WITHDRAWAL SYNDROME

Author(s)

HEIDARIANPOUR ALI | VAHIDIAN REZAZADEH MAJID | ZAMANI ALIREZA | Issue Writer Certificate

Keywords

INTERFERON-GAMMAQ2

INTERLEUKIN-17Q2

WITHDRAWAL SYNDROMEQ2

ENDURANCE TRAININGQ2

METHADONEQ1

Abstract

Objective: The aim of this study was to investigate the effect of 8 weeks of ENDURANCE TRAINING and METHADONE as an alternative to morphine on serum levels of INTERFERON-GAMMA and interleukin- 17.Materials and Methods: Twenty four male Wistar rats (220±10 g) were divided into four groups of Addicted Control (AC), Addicted Trained (AT), Addicted METHADONE (AM) and Addicted METHADONE Trained (AMT). All groups were made addicted with morphine sulfate 0.4 mg/mL (in 21 days). To ensure their dependence on morphine, Naloxone (3 mg/kg, i.p.) was injected into a number of the rats.Methadone hydrochloride powder was added to the drinking water AM and AMT groups. AT and AMT groups were made to run on treadmill for 8 weeks. Running time and speed gradually increased. Both prior to the exercises and 24 hours after the last training session, blood samples were collected from all the animals and the IFN-g and IL-17 serum levels were measured using the ELISA method.Results: Serum levels of INTERFERON-GAMMA increased in the AMT group compared with AM (P<0.001) and serum levels of IL- 17 showed a significant decrease (P<0.01). Also, a significant increase in serum levels of INTERFERON-GAMMA (P<0.01) and a significant decrease in the levels of IL-17 (P<0.001) was observed in the AT compared with the AMT.Conclusion: ENDURANCE TRAINING caused increased interferongamma and decreased INTERLEUKIN-17 in the active groups compared with the sedentary groups, and it had a greater effect on these cytokines during withdrawal. Therefore, this type of exercise can improve the function of the immune system during WITHDRAWAL SYNDROME.

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APA: Copy

HEIDARIANPOUR, ALI, VAHIDIAN REZAZADEH, MAJID, & ZAMANI, ALIREZA. (2014). EFFECT OF ENDURANCE TRAINING AND METHADONE ABUSE ON INTERFERON-GAMMA AND INTERLEUKIN-17 SERUM LEVELS IN MORPHINE-DEPENDENT RATS DURING WITHDRAWAL SYNDROME. SPORT AND BIOMOTOR SCIENCES, 6(1 (11)), 58-68. SID. https://sid.ir/paper/205304/en

Vancouver: Copy

HEIDARIANPOUR ALI, VAHIDIAN REZAZADEH MAJID, ZAMANI ALIREZA. EFFECT OF ENDURANCE TRAINING AND METHADONE ABUSE ON INTERFERON-GAMMA AND INTERLEUKIN-17 SERUM LEVELS IN MORPHINE-DEPENDENT RATS DURING WITHDRAWAL SYNDROME. SPORT AND BIOMOTOR SCIENCES[Internet]. 2014;6(1 (11)):58-68. Available from: https://sid.ir/paper/205304/en

IEEE: Copy

ALI HEIDARIANPOUR, MAJID VAHIDIAN REZAZADEH, and ALIREZA ZAMANI, “EFFECT OF ENDURANCE TRAINING AND METHADONE ABUSE ON INTERFERON-GAMMA AND INTERLEUKIN-17 SERUM LEVELS IN MORPHINE-DEPENDENT RATS DURING WITHDRAWAL SYNDROME,” SPORT AND BIOMOTOR SCIENCES, vol. 6, no. 1 (11), pp. 58–68, 2014, [Online]. Available: https://sid.ir/paper/205304/en

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