THE EFFECT OF AQUEOUS EXTRACT OF SAFFRON AND AEROBIC TRAINING ON CONCENTRATION OF HEPATIC NON-ENZYMATIC ANTIOXIDANT LEVELS IN STZ-INDUCED DIABETIC RATS

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PEERI M.; MOSALMAN HAGHIGHI M.; AZARBAYJANI M.A.; KHAJELOU A.

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Journal: JOURNAL OF SPORT BIOSCIENCE RESEARCHES Year:2012 | Volume:2 | Issue:7 Page(s): 5-16

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Title

THE EFFECT OF AQUEOUS EXTRACT OF SAFFRON AND AEROBIC TRAINING ON CONCENTRATION OF HEPATIC NON-ENZYMATIC ANTIOXIDANT LEVELS IN STZ-INDUCED DIABETIC RATS

Author(s)

PEERI M. | MOSALMAN HAGHIGHI M. | AZARBAYJANI M.A. | KHAJELOU A. | Issue Writer Certificate

Keywords

DIABETESQ1

SAFFRONQ1

GLUTATIONQ2

MALONDIALDEHYDEQ2

TACQ2

Abstract

Objective: The objective of the present study was to investigate the effect of combining aqueous extract of SAFFRON and aerobic training on the concentration of hepatic non-enzymatic antioxidants in the STZ-diabetic rats.Methodology: 41 male rats (age: 12 weeks, weight: 314±26.7 gr) were randomly assigned to five groups of healthy-control (HC, n=6), diabetic-control (DC, n=10), diabetic-aerobic training (DAT, n=10), diabetic-saffron (DS, n=10) and diabetic-aerobic training-saffron (DATS, n=5). Except for the healthy-control group, other groups were diabetic by injecting STZ. The diabetic-saffron and diabetic-aerobic training-saffron groups orally received 25 mg/kg aqueous extract of SAFFRON for two weeks per day. The diabetic-aerobic training and diabetic-aerobic training-saffron groups ran on a treadmill for two weeks, five consecutive sessions, with the speed of 12 m/min and slope of %0 for 30 min. Twenty-four hours after the last session of exercise, the rats were anesthetizing by chloroform and sacrificed; hepatic was taken from their bodies and was put in liquid and immediately kept in a deep freezer (-%70) in order to determine the concentration of MALONDIALDEHYDE (MDA), GLUTATION (GSH) and total antioxidant capacity (TAC).Findings: Analysis of variance (ANOVA) showed significant differences between the five groups at the levels of MALONDIALDEHYDE, GLUTATION and TAC (P= 0.001). The results of the Scheffe post hoc test demonstrated that the concentration of MALONDIALDEHYDE had a significant decrease in the SAFFRON-aerobic training (P= 0.001), diabetic-aerobic training (P=0.001) and SAFFRON-diabetic (P=0.001) groups compared with the diabetic-control group. The concentration of GLUTATION had the most and least increase in the SAFFRON-aerobic training and diabetic-control groups, respectively (P= 0.012). The concentration of TAC had the most and least increase in the SAFFRON-aerobic training and diabetic-control groups, respectively (P=0.005).Conclusion: The results of the present study demonstrated that the combination of SAFFRON extract and aerobic training would be appropriate method for reinforcing the hepatic non-enzymatic antioxidant system in diabetic rats.

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APA: Copy

PEERI, M., MOSALMAN HAGHIGHI, M., AZARBAYJANI, M.A., & KHAJELOU, A.. (2012). THE EFFECT OF AQUEOUS EXTRACT OF SAFFRON AND AEROBIC TRAINING ON CONCENTRATION OF HEPATIC NON-ENZYMATIC ANTIOXIDANT LEVELS IN STZ-INDUCED DIABETIC RATS. JOURNAL OF SPORT BIOSCIENCE RESEARCHES, 2(7), 5-16. SID. https://sid.ir/paper/240497/en

Vancouver: Copy

PEERI M., MOSALMAN HAGHIGHI M., AZARBAYJANI M.A., KHAJELOU A.. THE EFFECT OF AQUEOUS EXTRACT OF SAFFRON AND AEROBIC TRAINING ON CONCENTRATION OF HEPATIC NON-ENZYMATIC ANTIOXIDANT LEVELS IN STZ-INDUCED DIABETIC RATS. JOURNAL OF SPORT BIOSCIENCE RESEARCHES[Internet]. 2012;2(7):5-16. Available from: https://sid.ir/paper/240497/en

IEEE: Copy

M. PEERI, M. MOSALMAN HAGHIGHI, M.A. AZARBAYJANI, and A. KHAJELOU, “THE EFFECT OF AQUEOUS EXTRACT OF SAFFRON AND AEROBIC TRAINING ON CONCENTRATION OF HEPATIC NON-ENZYMATIC ANTIOXIDANT LEVELS IN STZ-INDUCED DIABETIC RATS,” JOURNAL OF SPORT BIOSCIENCE RESEARCHES, vol. 2, no. 7, pp. 5–16, 2012, [Online]. Available: https://sid.ir/paper/240497/en

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