STUDY OF THE EFFECT OF HYDRO-ALCHOLIC AND ESSENTIAL OIL OF ECHINOPHORA PLATYLOBA ON RAT ISOLATED ILEUM CONTRACTIONS IN VITRO

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ASGHARI G.; YAGHOBEI KH.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 150-155

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Title

STUDY OF THE EFFECT OF HYDRO-ALCHOLIC AND ESSENTIAL OIL OF ECHINOPHORA PLATYLOBA ON RAT ISOLATED ILEUM CONTRACTIONS IN VITRO

Author(s)

ASGHARI G. | YAGHOBEI KH. | Issue Writer Certificate

Keywords

ESSENTIAL OIL; HYDRO-ALCOHOLIC EXTRACT; ECHINOPHARO PLATYLOBA; ILEUM SMOOTH MUSCLE; INTESTINAL SPASM; ACETYLCHOLINE; KCLQ4

Abstract

Introduction. Echinophora platyloba is one of the unique plant in Iran which is traditionally used for flavoring of cheese and yogurt. So far there is no report on its pharmacological action. In this study, we have investigated the anti-spasmodic effect of hydro-alcoholic extract and essential oil of E. Platyloba on contraction of isolated ileum.Methods. For this purpose male wistar rats were killed with ablow on the head and aportion of ileum was removed and placed in oxygenated Tyrode's solution. Isotonic contraction induced by spasmogens (KCI and acetylcholine) were recorded on a physiograph chart recorder paper. Effect of series concentrations of essential oil were studied on tonic contraction induced by 80mM KCI in order to determine the range of concentrations of hydroalcoholic extract and essential oil which may have an inhibitory effect on ileum. Then two or three concentrations were selected and their effects were studied on acetylcholine concentration-response curve. Effect of hydro-alcoholic extract and essential oil were compared with control tissues treated with an equivalent volume of vehicle. In addition, effect of remaining solution after extraction of essential oil alone and with essential oil for comparison, were also studied.Results. Essential oil of E. platylobal in nl/ml bath concentration concentration-dependently inhibited ileum contraction (IC50= 75 ± 10.4 nl/ml) and attenuated the maximum response of acetylcholine concentration-response curve. The hydro-alcholic extract also concentration-dependently inhibited ileum contraction (IC50= 250 ± 12.1µg/ml). Effect of hydro-alcoholic extract on acetylcholine response qualitatively were similar to that of essential oil. The remaining solution following extraction of essential oil as when essential oil only has slight inhibitory effect and its combiation with the essential oil had a similar inhibitory effect as when essential oil were used alone.Discussion. Essential oil and hydro-alcoholic extract of E.platyloba relaxant effect on ileum contraction due to KCl and acetylcholine shows that they have anti-spasmodic activity on ileum smooth muscle. Since anti-spasmodic drugs are used for irritable bowl syndrome, the essential oil and hydro-alcoholic extract of E. platyloba can potentially be useful for control of abdominal cramps. However, as their anti-spasmodic effect appears in a special concentrations range and in high concentuations, they can completely inhibit intestinal contraction, determination of standard dosage for anti-spasmodic effect is necessary.

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APA: Copy

ASGHARI, G., & YAGHOBEI, KH.. (2003). STUDY OF THE EFFECT OF HYDRO-ALCHOLIC AND ESSENTIAL OIL OF ECHINOPHORA PLATYLOBA ON RAT ISOLATED ILEUM CONTRACTIONS IN VITRO. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 150-155. SID. https://sid.ir/paper/26679/en

Vancouver: Copy

ASGHARI G., YAGHOBEI KH.. STUDY OF THE EFFECT OF HYDRO-ALCHOLIC AND ESSENTIAL OIL OF ECHINOPHORA PLATYLOBA ON RAT ISOLATED ILEUM CONTRACTIONS IN VITRO. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):150-155. Available from: https://sid.ir/paper/26679/en

IEEE: Copy

G. ASGHARI, and KH. YAGHOBEI, “STUDY OF THE EFFECT OF HYDRO-ALCHOLIC AND ESSENTIAL OIL OF ECHINOPHORA PLATYLOBA ON RAT ISOLATED ILEUM CONTRACTIONS IN VITRO,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 150–155, 2003, [Online]. Available: https://sid.ir/paper/26679/en

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