A Case of Atypical Neuroleptic Malignant Syndrome following Clozapine Treatment

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SALEHI HOSSEIN; KHEIRKHAH FARZAN

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Journal: CURRENT RESEARCH IN MEDICAL SCIENCES Year:2018 | Volume:2 | Issue:2 Page(s): 15-19

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Title

A Case of Atypical Neuroleptic Malignant Syndrome following Clozapine Treatment

Author(s)

SALEHI HOSSEIN | KHEIRKHAH FARZAN | Issue Writer Certificate

Keywords

Neuroleptic Malignant Syndrome (NMS)

Antipsychotic agents

Schizophrenia

Clozapine

Abstract

Background and Objective: Neuroleptic Malignant Syndrome (NMS) is an adverse effect of antipsychotic medication. Here, we described an atypical NMS case following treatment with Clozapine, without the main clinical features (fever and rigidity) of NMS. Case report: This report described a rare case of NMS in a 49-year old male with Schizophrenia, under treatment with 500mg/day Clozapine since 5 months ago, and admitted for evaluation of altered mental status. Additional clinical findings included severe diaphoresis, fluctuating blood pressure and tachycardia. After diagnosis of NMS, treatment with supportive and pharmaco-therapeutic measures were immediately initiated, resulting in complete resolution of symptoms. He was discharged with 30mg aripiprazole daily and presents no side effects in 4 years of follow up. Conclusion: Although NMS can be easily recognized in typical presentation, but it could be consist of different types of onset, clinical findings and course, and also it can present a benign prognosis if recognized and treated early.

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APA: Copy

SALEHI, HOSSEIN, & KHEIRKHAH, FARZAN. (2018). A Case of Atypical Neuroleptic Malignant Syndrome following Clozapine Treatment. CURRENT RESEARCH IN MEDICAL SCIENCES, 2(2 ), 15-19. SID. https://sid.ir/paper/269263/en

Vancouver: Copy

SALEHI HOSSEIN, KHEIRKHAH FARZAN. A Case of Atypical Neuroleptic Malignant Syndrome following Clozapine Treatment. CURRENT RESEARCH IN MEDICAL SCIENCES[Internet]. 2018;2(2 ):15-19. Available from: https://sid.ir/paper/269263/en

IEEE: Copy

HOSSEIN SALEHI, and FARZAN KHEIRKHAH, “A Case of Atypical Neuroleptic Malignant Syndrome following Clozapine Treatment,” CURRENT RESEARCH IN MEDICAL SCIENCES, vol. 2, no. 2 , pp. 15–19, 2018, [Online]. Available: https://sid.ir/paper/269263/en

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