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Information Journal Paper

Title

EFFECTS OF EPA AND VITAMIN E ON SERUM ENZYMATIC ANTIOXIDANTS AND PEROXIDATION INDICES IN PATIENTS WITH TYPE II DIABETES MELLITUS

Pages

  82-91

Abstract

 Background: Diabetes mellitus is associated with chronic changes in peripheral arteries because of oxidative stress and insufficient antioxidative defense mechanism. Omega-3 fatty acid supplementation could be effective in some diabetes complications; however, polyunsaturated fatty acids may increase lipid per oxidation. This study aimed to determine whether eicosapentaenoic acid alone or in conjunction with vitamin E had differential effects on serum antioxidants and peroxidation indices.Methods: This double-blind, placebo-controlled trial was carried out on 136 patients with type II diabetic mellitus (age 48.8±4.4 yr, BMI 27.8±1.7 kg/m2). The four groups of the study either received two grams of omega-3 fatty acids, 400 IU of vitamin E, a combination of the two or placebo for three months. Their serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices were assessed.Result: Fasting serum TAC increased in EPA+E (10.7%, P<0.001) and E groups (7.5%, P<0.05). SOD, G-PX and G-RD increased in EPA group (7.3%, 5.1%, and 8.4%, P<0.05, respectively). MDA and protein carbonyl decreased in EPA and E groups (respectively, 12.5%, 7.6% P<0.05, P<0.05; 13%, 15.3% P<0.001, P<0.05). After adjustment for baseline values, age, sex, BMI and duration of diagnosed diabetes, protein carbonyl decreased in EPA+E and E group (30.7%, 15.3%, P<0.05 respectively) relative to the placebo group.Conclusion: EPA, by itself has a statistically significant effect on serum total antioxidant capacity, enzymatic antioxidants and peroxidation indices in diabetic patients compared to EPA+E or E alone.Trial registration: ClinicalTrials.gov NCT00817622.

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    Cite

    APA: Copy

    SARBOLOUKI, SH., DJALALI, M., DJAZAYERI, S.A., ESHRAGHIAN, M.R., EBADI, S.A.R., & HASHEMI, S.B.. (2010). EFFECTS OF EPA AND VITAMIN E ON SERUM ENZYMATIC ANTIOXIDANTS AND PEROXIDATION INDICES IN PATIENTS WITH TYPE II DIABETES MELLITUS. IRANIAN JOURNAL OF PUBLIC HEALTH, 39(3), 82-91. SID. https://sid.ir/paper/272735/en

    Vancouver: Copy

    SARBOLOUKI SH., DJALALI M., DJAZAYERI S.A., ESHRAGHIAN M.R., EBADI S.A.R., HASHEMI S.B.. EFFECTS OF EPA AND VITAMIN E ON SERUM ENZYMATIC ANTIOXIDANTS AND PEROXIDATION INDICES IN PATIENTS WITH TYPE II DIABETES MELLITUS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2010;39(3):82-91. Available from: https://sid.ir/paper/272735/en

    IEEE: Copy

    SH. SARBOLOUKI, M. DJALALI, S.A. DJAZAYERI, M.R. ESHRAGHIAN, S.A.R. EBADI, and S.B. HASHEMI, “EFFECTS OF EPA AND VITAMIN E ON SERUM ENZYMATIC ANTIOXIDANTS AND PEROXIDATION INDICES IN PATIENTS WITH TYPE II DIABETES MELLITUS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 39, no. 3, pp. 82–91, 2010, [Online]. Available: https://sid.ir/paper/272735/en

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