Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

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Motaghi a.a.; AGHABABA H.; HEYDARI M.; HOSSEINI S.S.; ZAREI A.; Voghofi r.; CHANGIZI ASHTIYANI S.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2019 | Volume:20 | Issue:6 Page(s): 312-319

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Title

Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

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Keywords

DiabetesQ3

ZiziphoraQ1

Blood glucoseQ3

Blood lipidsQ2

Abstract

Introduction: Diabetes is a common metabolic disorder associated with an increased risk of cardiovascular disease, disability, and mortality. The present study was conducted to evaluate the effects of alcoholic extract of Ziziphora tenuior L (Ziziphora) plant on Blood glucose and fat profiles in streptozotocin-induced diabetic rats. Materials and Methods: In this study, 40 male wistar rats were divided into five groups: control, diabetic control, experimental group receiving dose 50, 75 and 100 mg/kg of hydoalcholic exctract of Ziziphora. Diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg). After 28 days, the extract was gavaged, blood samples were collected and biochemical analysis was performed to determine the levels of glucose, insulin and lipid profiles in the serum. Results: The alcoholic extract of Ziziphora consumed three in all doses significantly increased body weight, insulin and decreased Blood glucose but did not have a significant effect on cholesterol, HDL and LDL. Conclusion: Oral administration of the hydroalcholic extract of the Ziziphora probably leads to a decrease in Blood glucose in type 1 diabetic rats by increasing insulin secretion.

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APA: Copy

Motaghi, a.a., AGHABABA, H., HEYDARI, M., HOSSEINI, S.S., ZAREI, A., Voghofi, r., & CHANGIZI ASHTIYANI, S.. (2019). Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 20(6 ), 312-319. SID. https://sid.ir/paper/27749/en

Vancouver: Copy

Motaghi a.a., AGHABABA H., HEYDARI M., HOSSEINI S.S., ZAREI A., Voghofi r., CHANGIZI ASHTIYANI S.. Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2019;20(6 ):312-319. Available from: https://sid.ir/paper/27749/en

IEEE: Copy

a.a. Motaghi, H. AGHABABA, M. HEYDARI, S.S. HOSSEINI, A. ZAREI, r. Voghofi, and S. CHANGIZI ASHTIYANI, “Effect of Alcoholic Extract of Ziziphora tenuior L on Blood Glucose and Lipid Profiles in Streptozotocin-Induced Diabetic Rats,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 20, no. 6 , pp. 312–319, 2019, [Online]. Available: https://sid.ir/paper/27749/en

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