A PRELIMINARY INVESTIGATION OF THE JACK-BEAN UREASE INHIBITION BY RANDOMLY SELECTED TRADITIONALLY USED HERBAL MEDICINE

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BIGLAR MAHMOOD; SOLTANI KHADIJEH; NABATI FARZANEH; BAZL ROYA; MOJAB FARAZ; AMANLOU MASSOUD

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:3 Page(s): 831-837

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Title

A PRELIMINARY INVESTIGATION OF THE JACK-BEAN UREASE INHIBITION BY RANDOMLY SELECTED TRADITIONALLY USED HERBAL MEDICINE

Author(s)

Keywords

HERBAL EXTRACT

UREASE

INHIBITOR

INDOPHENOL METHOD

LEAD DISCOVERY

Abstract

Helicobacter pylori (H. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. The most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or synthetic anti-H. pylori agents. In this report 21 randomly selected herbal methanolic extracts were evaluated for their effect on inhibition of Jack-bean UREASE using the INDOPHENOL METHOD as described by Weatherburn. The inhibition potency was measured by UV spectroscopy technique at 630 nm which attributes to released ammonium. Among these extracts, five showed potent INHIBITORy activities with IC50 ranges of 18-35 mg/mL. These plants are Matricaria disciforme (IC50:35 mg/mL), Nasturtium officinale (IC50:18 mg/mL), Punica granatum (IC50:30 mg/mL), Camelia sinensis (IC50:35 mg/mL), Citrus aurantifolia (IC50:28 mg/mL).

Cites

GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES

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APA: Copy

BIGLAR, MAHMOOD, SOLTANI, KHADIJEH, NABATI, FARZANEH, BAZL, ROYA, MOJAB, FARAZ, & AMANLOU, MASSOUD. (2012). A PRELIMINARY INVESTIGATION OF THE JACK-BEAN UREASE INHIBITION BY RANDOMLY SELECTED TRADITIONALLY USED HERBAL MEDICINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(3), 831-837. SID. https://sid.ir/paper/287982/en

Vancouver: Copy

BIGLAR MAHMOOD, SOLTANI KHADIJEH, NABATI FARZANEH, BAZL ROYA, MOJAB FARAZ, AMANLOU MASSOUD. A PRELIMINARY INVESTIGATION OF THE JACK-BEAN UREASE INHIBITION BY RANDOMLY SELECTED TRADITIONALLY USED HERBAL MEDICINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(3):831-837. Available from: https://sid.ir/paper/287982/en

IEEE: Copy

MAHMOOD BIGLAR, KHADIJEH SOLTANI, FARZANEH NABATI, ROYA BAZL, FARAZ MOJAB, and MASSOUD AMANLOU, “A PRELIMINARY INVESTIGATION OF THE JACK-BEAN UREASE INHIBITION BY RANDOMLY SELECTED TRADITIONALLY USED HERBAL MEDICINE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 3, pp. 831–837, 2012, [Online]. Available: https://sid.ir/paper/287982/en

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