STUDY OF THE PROTECTIVE EFFECT OF TEUCRIUM POLIUM L. EXTRACT ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FOROUZANDEH HOSSEIN; AZEMI MOHAMMAD EBRAHIM; RASHIDI IRAN; GOUDARZI MAHDI; KALANTARI HEIBATULLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:1 Page(s): 123-129

Download Full-Text

View:

341

Download:

229

Cites:

Information Journal Paper

Title

STUDY OF THE PROTECTIVE EFFECT OF TEUCRIUM POLIUM L. EXTRACT ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE

Author(s)

Keywords

HEPATOTOXICITY

ACETAMINOPHEN

TEUCRIUM POLIUM L

PROTECTIVE

Abstract

In the present study, PROTECTIVE effect of TEUCRIUM POLIUM L. (Labiatae) extract on ACETAMINOPHEN-induced HEPATOTOXICITY was investigated in mice. Animals were divided into six groups, each group consist of 8 mice. Group one as the negative control group received normal saline, while group two received only crude extract of T. polium L. (500 mg/Kg) for five days and group three as the positive group received ACETAMINOPHEN (500 mg/Kg). Groups four, five and six received crude extract in doses of 125, 250 and 500 mg/Kg, respectively, and on the fifth day, one hour after the last administration, ACETAMINOPHEN was given orally (500 mg/Kg). Then on the 6th day, animals were sacrificed, their blood was collected to determine serum enzyme activities of ALT, AST and ALP to measure the serum levels of directed and total bilirubin. The livers were removed for histological examination. The results of this study showed the PROTECTIVE effect in all doses but the most significant protection was observed in doses of 250 and 500 mg/Kg (p<0.05). Also these findings were supported and confirmed by histological examination.

Cites

ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS

References

No record.

Cite

APA: Copy

FOROUZANDEH, HOSSEIN, AZEMI, MOHAMMAD EBRAHIM, RASHIDI, IRAN, GOUDARZI, MAHDI, & KALANTARI, HEIBATULLAH. (2013). STUDY OF THE PROTECTIVE EFFECT OF TEUCRIUM POLIUM L. EXTRACT ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(1), 123-129. SID. https://sid.ir/paper/288079/en

Vancouver: Copy

FOROUZANDEH HOSSEIN, AZEMI MOHAMMAD EBRAHIM, RASHIDI IRAN, GOUDARZI MAHDI, KALANTARI HEIBATULLAH. STUDY OF THE PROTECTIVE EFFECT OF TEUCRIUM POLIUM L. EXTRACT ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(1):123-129. Available from: https://sid.ir/paper/288079/en

IEEE: Copy

HOSSEIN FOROUZANDEH, MOHAMMAD EBRAHIM AZEMI, IRAN RASHIDI, MAHDI GOUDARZI, and HEIBATULLAH KALANTARI, “STUDY OF THE PROTECTIVE EFFECT OF TEUCRIUM POLIUM L. EXTRACT ON ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 1, pp. 123–129, 2013, [Online]. Available: https://sid.ir/paper/288079/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops