EFFECT OF MYRTUS COMMUNIS L. SYRUP ON CHRONIC RHINOSINUSITIS: ARANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT STUDY

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ABRISHAMKAR MAHBOOBEH; KAMALINEJAD MOHAMMAD; JAFARI ROZITA; CHAIBAKHSH SAMIRA; KARIMI MEHRDAD; GHORBANI JAHANGIR; JAFARI ZAHRA; EMTIAZY MAJID

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Journal: Iranian Red Crescent Medical Journal Year:2017 | Volume:19 | Issue:12 Page(s): 0-0

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Title

EFFECT OF MYRTUS COMMUNIS L. SYRUP ON CHRONIC RHINOSINUSITIS: ARANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT STUDY

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Abstract

Background: According to the Iranian Traditional Medicine (ITM) resources, myrtle (Myrtus communis L. ) resolves swelling, woundsand injuries; itswoundexsiccation capability and tissue enforcement propertiesmaybe helpful in the treatment of the rhinosinusitis. Objectives: The objective of the current trial was to assess the effects of Myrtus communis aqueous extract in the treatment of chronicrhinosinusitis. Methods: A total of 38 patients referring to the Masih Daneshvari Hospital (Tehran, Iran) for the treatment of chronic rhinosinusitisduring the year 2016 were recruited for a double-blinded randomized placebo-controlled trial. They were randomly allocated in 2groups: 22 patients were in the treatment group and 16 patients in the placebo group. Recruitment was based on the European positionpaper on rhinosinusitis (EPOS). Patients’ data, including demographic information, SNOT22 questionnaire scores, and visualanalog scale (VAS), were gathered and recorded by an otolaryngologist. Patients were investigated with a CT scan of the paranasalsinuses at the beginning of the study. Results: A total of 13 patients (59. 1%) in the treatment group were female and 7 in the placebo group (43. 7%). The median age ofpatients in the treatment group was 38. 86 (18-68)andin the placebo group 39. 93 (22-75) years. Data analysis revealed thatsymptomsimproved in the treatment group after treatment in most parameters, according to the SNOT-22 parameters. However, most of theseimprovements, such as reduced concentration (1. 81 2. 01 vs. 0. 73 1. 32 in control vs. treatment group, respectively; P = 0. 055), frustrated/restless/irritable (1. 56 1. 97 vs. 0. 55 1. 1 in control and treatment groups, respectively; P = 0. 113), as well as ear pain(P = 0. 121), did not demonstrate a statistical significance. There was a significant improvement in symptom number 18 (reducedproductivity) in the SNOT-22 questionnaire (1. 69 1. 92 vs. 0. 77 1. 23 in control vs. treatment group, respectively; P = 0. 041). Conclusions: According to the present study findings, Myrtus communis L. syrup can be safely administered in patients with chronicrhinosinusitis and is effective in improving the outcomes of the disease.

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