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Information Journal Paper

Title

Protective Effects of Artemisia persica Essential Oil Against Pentylenetetrazol-Induced Seizure in Male Mice with Emphasizing Its Mechanism of Action

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Abstract

 Background: A new approach in the treatment of epilepsy is to use new drugs with neuroprotective, antioxidant, and antiinflammatory effects. Objectives: The study aimed to investigate the protective effects of Artemisia persica essential oil (EO) against Pentylenetetrazol (PTZ)-induced seizure in mice. Methods: This experimental study was conducted at the Izeh Islamic Azad University, Iran. 70 male BALB/c mice were divided into seven groups of 10 using simple random allocation, including control (normal saline), PTZ (35 mg/kg i. p. with 48 hours intervals and then 60 mg/kg on the 10th day), interventions (PTZ plus daily i. p. injection of EO at doses of 50, 75, and 100 mg/kg), Diazepam (PTZ plus EO at a dose of 100 mg/kg + Diazepam), and Flumazenil (PTZ plus EO at a dose of 100 mg/kg + Flumazenil) groups. Results: The treatment of PTZ-kindled mice with 50 mg/kg of EO significantly reduced the seizure onset latency (P < 0. 05). EO at a dose of 100 mg/kg significantly decreased tonic Seizures, head tics, and repeated spinning and jumping (P < 0. 05). Diazepam improved, and Flumazenil weakened the anticonvulsant effects of the EO. The treatment of PTZ-kindled mice with EO (100 mg/kg) significantly decreased nitric oxide and malondialdehyde, and increased the total antioxidant capacity in both serum and brain (P < 0. 05). EO at a dose of 100 mg/kg could significantly decrease IL-1 and TNF- expression in the brain of epileptic mice (P < 0. 05). Conclusions: A. persica EO shows anticonvulsant effects through benzodiazepine receptor binding activity and modulation of oxidative stress and the inflammatory process.

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APA: Copy

Daneshkhah, Mojgan, & SETORKI, MAHBUBEH. (2019). Protective Effects of Artemisia persica Essential Oil Against Pentylenetetrazol-Induced Seizure in Male Mice with Emphasizing Its Mechanism of Action. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(2), 0-0. SID. https://sid.ir/paper/293862/en

Vancouver: Copy

Daneshkhah Mojgan, SETORKI MAHBUBEH. Protective Effects of Artemisia persica Essential Oil Against Pentylenetetrazol-Induced Seizure in Male Mice with Emphasizing Its Mechanism of Action. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(2):0-0. Available from: https://sid.ir/paper/293862/en

IEEE: Copy

Mojgan Daneshkhah, and MAHBUBEH SETORKI, “Protective Effects of Artemisia persica Essential Oil Against Pentylenetetrazol-Induced Seizure in Male Mice with Emphasizing Its Mechanism of Action,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/293862/en

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