STUDY OF NUMBER AND FUNCTION OF T4 AND T8 CELLS WITH RESPECT TO SURFACE MARKERS IN CHEMICALLY INJURED PEOPLE

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SHAKER Z.; MOHAMMAD HASAN ZOHEYR; SOHRABPOUR H.; MOSAFA N.

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Journal: HAKIM RESEARCH JOURNAL Year:2001 | Volume:4 | Issue:2 Page(s): 142-148

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Title

STUDY OF NUMBER AND FUNCTION OF T4 AND T8 CELLS WITH RESPECT TO SURFACE MARKERS IN CHEMICALLY INJURED PEOPLE

Author(s)

SHAKER Z. | MOHAMMAD HASAN ZOHEYR | SOHRABPOUR H. | MOSAFA N. | Issue Writer Certificate

Keywords

SULFUR MUSTARDQ4

NITROGEN MUSTARDQ4

T CELLQ4

Abstract

Exposure to SULFUR MUSTARD results in short-term and long-term complications in injured people. The short-term complications are such as dermal depigmentation and blisters of the skin, respiratory disturbances and ophtalmologic symptoms like conjunctivitis. The long-term complications consist of chronic bronchitis, severe asthma and higher incidence of malignancy. The exposure to mustard gas also affects the hematopoietic and immune systems. T cells are a major component of most aquired immune responses. Its functions can be influenced by exposure to toxic agents such as mustard gas. Such adverse effects attenuate defence mechanisms which would otherwise operate to eliminate mutated cells, leading to a higher risk of neoplastic transformation. In this study 75 chemical weapon victims of the war between Iran and Iraq were devided in three groups depending on the severity of the complications (mild, moderate and severe). In addition ten subjects were not exposed to SULFUR MUSTARD comprised as the control group. Five milliliter of peripheral blood were collected from 85 subjects" and analysed for complete blood count, cell morphology and flow cytometry. Cell morphology was analysed by blood smear preparation and light microscopic examination under 100X objective. Blood parameters including WBC, RBC platelet counts and hemoglubin concentration were calculated using a Sysmex K-1000. Besides, blood cells were analyzed for CD45, CD3, CD4, CDS and CD25 cell markers. CD45+ / CD3+ /CD4+ were regarded as T helper cells (TH), and CD45+ / CDS+ T CELLs were considered cytotoxic T CELLs (Tc). CD25 expression was used as an activation marker. Statistical analysis of data were "performed using analysis "of variance (ANOVA) and Least Significant Difference tests. The higher expression of CD25 on CD3+/ CD4+ T CELLs suggets immune activation most probably resulted from recurrent infection such as bacterial pneumonia seen frequently in these patients. On the other hand, Lower numbers of CD8+ T CELLs may contribute to higher incidence of malignancy in these patients.

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APA: Copy

SHAKER, Z., MOHAMMAD HASAN, ZOHEYR, SOHRABPOUR, H., & MOSAFA, N.. (2001). STUDY OF NUMBER AND FUNCTION OF T4 AND T8 CELLS WITH RESPECT TO SURFACE MARKERS IN CHEMICALLY INJURED PEOPLE. HAKIM RESEARCH JOURNAL, 4(2), 142-148. SID. https://sid.ir/paper/29492/en

Vancouver: Copy

SHAKER Z., MOHAMMAD HASAN ZOHEYR, SOHRABPOUR H., MOSAFA N.. STUDY OF NUMBER AND FUNCTION OF T4 AND T8 CELLS WITH RESPECT TO SURFACE MARKERS IN CHEMICALLY INJURED PEOPLE. HAKIM RESEARCH JOURNAL[Internet]. 2001;4(2):142-148. Available from: https://sid.ir/paper/29492/en

IEEE: Copy

Z. SHAKER, ZOHEYR MOHAMMAD HASAN, H. SOHRABPOUR, and N. MOSAFA, “STUDY OF NUMBER AND FUNCTION OF T4 AND T8 CELLS WITH RESPECT TO SURFACE MARKERS IN CHEMICALLY INJURED PEOPLE,” HAKIM RESEARCH JOURNAL, vol. 4, no. 2, pp. 142–148, 2001, [Online]. Available: https://sid.ir/paper/29492/en

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