ACTIVATION OF NITRIC OXIDE SYNTHASE IN THE RAT HIPPOCAMPUS POTENTIATES THE PLACE CONDITIONING-INDUCED BY MORPHINE

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KARAMI M.; SAHRAEI HEDAYAT; ZARINDAST M.R.; SEPEHRI H.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2003 | Volume:10 | Issue:46 Page(s): 69-74

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Title

ACTIVATION OF NITRIC OXIDE SYNTHASE IN THE RAT HIPPOCAMPUS POTENTIATES THE PLACE CONDITIONING-INDUCED BY MORPHINE

Author(s)

KARAMI M. | SAHRAEI HEDAYAT | ZARINDAST M.R. | SEPEHRI H. | Issue Writer Certificate

Keywords

HIPPOCAMPUSQ2

NITROICXIDE SYNTHASEQ4

PLACE CONDITIONINGQ4

MORPHINEQ2

Abstract

Opioids have the ability to induce the reinforcing effects mainly by activation of dopaminergic system, but can also play a role in learning processes. In this research, effects of Nitric Oxide (NO) agents on MORPHINE-induced PLACE CONDITIONING were studied by using an Unbiased procedure. Male Wistar rats (220- 250 g) were implanted with two cannulae and MORPHINE administered according to a three-day schedule of conditioning. To survey the effects of intra-hippocampal injections of L-arginine, a NO precursor or L-NAME, a NO synthase inhibitor, on the aquisition and expression of MORPHINE PLACE CONDITIONING, L-arginine or L-NAME repeatedly (once per day, for three days) or once/testing day, bilaterally injected at 0.3-3 µg/ rat into the CA1 area of the HIPPOCAMPUS of rats. Data showed that both repeated and once injections of L- arginine at above-mentioned doses, led to significant enhancement of MORPHINE-induced conditioning. L-NAME, on the other hand had no interaction to MORPHINE.Mediation of NO system in HIPPOCAMPUS associated phenomena such as learning and memory have been shown. Evidence also suggests that dopaminergic system is involved in modulating the memory processes and that NO is a neuronal messenger mediating the release of dopamine. Thus, NO may be a neuronal messenger causing the release of dopamine in the CA1 area of the rat HIPPOCAMPUS by which the enhanced MORPHINE-induced PLACE CONDITIONING in this experiment could be explained. Considering the results of this research, L-NAME failed to interact to MORPHINE. Perhaps this result can be explained to consider the different efficacy of NOS inhibitors in affecting the MORPHINE response. Regarding the present results, we may conclude that NO system in the rat HIPPOCAMPUS plays a role in MORPHINE- induced PLACE CONDITIONING.

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APA: Copy

KARAMI, M., SAHRAEI, HEDAYAT, ZARINDAST, M.R., & SEPEHRI, H.. (2003). ACTIVATION OF NITRIC OXIDE SYNTHASE IN THE RAT HIPPOCAMPUS POTENTIATES THE PLACE CONDITIONING-INDUCED BY MORPHINE. DANESHVAR MEDICINE, 10(46), 69-74. SID. https://sid.ir/paper/30445/en

Vancouver: Copy

KARAMI M., SAHRAEI HEDAYAT, ZARINDAST M.R., SEPEHRI H.. ACTIVATION OF NITRIC OXIDE SYNTHASE IN THE RAT HIPPOCAMPUS POTENTIATES THE PLACE CONDITIONING-INDUCED BY MORPHINE. DANESHVAR MEDICINE[Internet]. 2003;10(46):69-74. Available from: https://sid.ir/paper/30445/en

IEEE: Copy

M. KARAMI, HEDAYAT SAHRAEI, M.R. ZARINDAST, and H. SEPEHRI, “ACTIVATION OF NITRIC OXIDE SYNTHASE IN THE RAT HIPPOCAMPUS POTENTIATES THE PLACE CONDITIONING-INDUCED BY MORPHINE,” DANESHVAR MEDICINE, vol. 10, no. 46, pp. 69–74, 2003, [Online]. Available: https://sid.ir/paper/30445/en

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