The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats

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SHERAFATI MOGHADAM MOHAMMAD; DARYANOOSH FARHAD; SALESI MOHSEN; FALLAHI ALIASGHAR; HEMATI NAFAR MOHAMMAD

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Journal: DANESHVAR MEDICINE Year:2019 | Volume:27 | Issue:140 Page(s): 1-10

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Title

The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats

Author(s)

Keywords

High intensity interval training (HIIT)Q1

mTORC1 signaling pathwayQ1

FHL skeletal muscleQ1

Type 2 diabetesQ2

Abstract

Background and Objective The most well-known mechanism for regulating complex mammalian target of rapamycin 1 (mTORC1) pathway activity is the insulin/IGF-1-dependent pathway in skeletal muscles. The role of high intensity interval training (HIIT) exercise has not yet been studied on this important pathway in protein synthesis among people with Type 2 diabetes. The purpose of the present study was to investigate the effects of HIIT on mTORC1 pathway in Flexor hallucis longus muscle (FHL) of streptozotocin (STZ)-induced diabetic rats. Materials and Methods In this experimental study, sixty male Sprague– Dawley rats with a weight of 260± 20 g were randomly assigned into two equal groups including control group (n= 8) and HIIT trained group (n=8) after inducing diabetes in them by STZ and nicotinamide. The latter group of rats were trained in accordance with the training program for 4 weeks (4 sessions per week). Control groups received no exercise intervention. Furthermore, rats did not receive any insulin therapy during the study period. Independent t-test was used to assess the difference between the groups. Differences were considered significant at p<0. 05. Results There was a significant increase in the value of AKT1 (p<0. 005), mTORC1 (p<0. 0001), P70S6K1 (p<0. 008) and 4E-BP1 (p<0. 001) proteins in the HIIT trained group as compared to the control group. Conclusion Given the increase in the content of these proteins (AKT1, mTORC1, P70S6K1 and 4E-BP1) in the FHL skeletal muscle tissue of type 2 diabetic subjects and their important role in protein synthesis, HIIT's exercise may be considered as an important approach for increasing protein synthesis or muscle hypertrophy in these individuals.

Cites

THE EFFECT OF ENDURANCE TRAINING ON PROTEIN KINASE-B AND MECHANICAL TARGET OF RAPAMYCIN IN THE LEFT VENTRICLE OF THE HEART OF DIABETIC RATS INDUCED BY STREPTOZOTOCIN AND NICOTINAMIDE

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APA: Copy

SHERAFATI MOGHADAM, MOHAMMAD, DARYANOOSH, FARHAD, SALESI, MOHSEN, FALLAHI, ALIASGHAR, & HEMATI NAFAR, MOHAMMAD. (2019). The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats. DANESHVAR MEDICINE, 27(140 ), 1-10. SID. https://sid.ir/paper/30502/en

Vancouver: Copy

SHERAFATI MOGHADAM MOHAMMAD, DARYANOOSH FARHAD, SALESI MOHSEN, FALLAHI ALIASGHAR, HEMATI NAFAR MOHAMMAD. The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats. DANESHVAR MEDICINE[Internet]. 2019;27(140 ):1-10. Available from: https://sid.ir/paper/30502/en

IEEE: Copy

MOHAMMAD SHERAFATI MOGHADAM, FARHAD DARYANOOSH, MOHSEN SALESI, ALIASGHAR FALLAHI, and MOHAMMAD HEMATI NAFAR, “The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats,” DANESHVAR MEDICINE, vol. 27, no. 140 , pp. 1–10, 2019, [Online]. Available: https://sid.ir/paper/30502/en

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