IGM+CD5+ CELLS IN CANCEROUS MURINE MODEL USING BCL1 CELL LINE

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ABDOLMALEKI MOHSEN; KHEIRANDISH MARYAM; SARRAFNEJAD ABDOLFATTAH; SEDAGHAT REZA; MOSAFFA NARIMAN; YARAEE ROYA

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Journal: DANESHVAR MEDICINE Year:2017 | Volume:24 | Issue:130 Page(s): 1-12

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Title

IGM+CD5+ CELLS IN CANCEROUS MURINE MODEL USING BCL1 CELL LINE

Author(s)

Keywords

CANCERQ2

ANIMAL MODELQ2

BCL-1Q1

SPLEENQ2

BLOOD LEUKOCYTESQ1

IGMQ3

CD5Q1

Abstract

Background: ANIMAL MODELs are crucial for the development of new therapies, especially in serious diseases such as CANCER. In this study, CANCER (leukemia) was established by an injection of CANCERous cells and followed by evaluating cell markers in SPLEEN and blood.Materials and Methods: 5×106 BCL-1 cells were injected through tail vein into syngenic BALB/c mice. Then, 5 mice were killed after two weeks and 5 after four weeks and changes in SPLEEN index, peripheral BLOOD LEUKOCYTES and histology of organs were assessed. SPLEEN and blood cells were evaluated by flow cytometry using IGM and CD5 as markers of CANCER cells.Results: SPLEEN index was increased in injected groups statistically significant (p<0.05) and the most increase was observed in SPLEEN area of the 4-week group (about 1.5 fold of control group). Lymphocyte to the neutrophil ratio in peripheral blood smear was augmented from 4.9 to 8.8 (p<0.05). The percentage of IGM+CD5+cells in the SPLEEN increased from 2.5% in the control group to 14% in 2 weeks and 32% in 4-weeks group. In the histological examination of the SPLEENs, the white pulp was developed.Conclusion: In this method, CANCER cells were established in animals. Changes in SPLEEN size, blood cells ratio and the percentage of IGM+CD5+cells in SPLEEN can be used to track the status of the establishment of CANCER cells in animals and could be considered as indicators to use for research on new therapies.

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References

ISOLATION OF B-1 SUBTYPE B LYMPHOCYTES FROM HUMAN CORD BLOOD

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APA: Copy

ABDOLMALEKI, MOHSEN, KHEIRANDISH, MARYAM, SARRAFNEJAD, ABDOLFATTAH, SEDAGHAT, REZA, MOSAFFA, NARIMAN, & YARAEE, ROYA. (2017). IGM⁺CD5⁺ CELLS IN CANCEROUS MURINE MODEL USING BCL1 CELL LINE. DANESHVAR MEDICINE, 24(130), 1-12. SID. https://sid.ir/paper/30577/en

Vancouver: Copy

ABDOLMALEKI MOHSEN, KHEIRANDISH MARYAM, SARRAFNEJAD ABDOLFATTAH, SEDAGHAT REZA, MOSAFFA NARIMAN, YARAEE ROYA. IGM⁺CD5⁺ CELLS IN CANCEROUS MURINE MODEL USING BCL1 CELL LINE. DANESHVAR MEDICINE[Internet]. 2017;24(130):1-12. Available from: https://sid.ir/paper/30577/en

IEEE: Copy

MOHSEN ABDOLMALEKI, MARYAM KHEIRANDISH, ABDOLFATTAH SARRAFNEJAD, REZA SEDAGHAT, NARIMAN MOSAFFA, and ROYA YARAEE, “IGM⁺CD5⁺ CELLS IN CANCEROUS MURINE MODEL USING BCL1 CELL LINE,” DANESHVAR MEDICINE, vol. 24, no. 130, pp. 1–12, 2017, [Online]. Available: https://sid.ir/paper/30577/en

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