INVESTIGATION OF THE PROLIFERATION RESPONSE OF LYMPHOCYTES FROM MULTIPLE SCLEROSIS PATIENTS TO BORRELIA ANTIGENS

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RAHMANI MANIZHEH; MOAZENI S.M.; SANATI M.H.

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Journal: DANESHVAR MEDICINE Year:2004 | Volume:11 | Issue:48 Page(s): 7-12

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Title

INVESTIGATION OF THE PROLIFERATION RESPONSE OF LYMPHOCYTES FROM MULTIPLE SCLEROSIS PATIENTS TO BORRELIA ANTIGENS

Author(s)

RAHMANI MANIZHEH | MOAZENI S.M. | SANATI M.H. | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ3

PROLIFERATION RESPONSEQ3

BORRELIAQ3

Abstract

MULTIPLE SCLEROSIS (MS) is a chronic inflammatory disease of central nervous system. In this disease the blood brain barrier (BBB) is damaged by an unknown factor, so that macrophages and lymphocytes which infiltrate the central nervous system cause the demyelination of nerves, and produce some disorders in the normal functions of the neurons.Because of the special importance of T lymphocyte in MS pathogenesis and regarding the old hypothesis of spirochetal basis of MS due to close similarities between clinical manifestation and pathogenesis of MS and spirochetallyme disease, for investigation of the probable role of bonoeliain MS manifestation we decided to study the response of MS patient's T lymphocytes, against BORRELIA antigens. For this purpose the PROLIFERATION RESPONSE of T lymphocytes from 45 MS patients against BORRELIA antigens was compared with 38 ages and sex matched normal persons using the lymphocyte transformation test (LTT). Two outer surface proteins of BORRELIA (OspA & OspD) that were prepared by recombinant technology were also included in the study.Our results showed that, however there are some differences in PROLIFERATION RESPONSE of T lymphocytes from MS patients and normal individuals, against BORRELIA whole antigens, but these differences are not statistically significant. However comparing with PROLIFERATION RESPONSE to PHA which showed that T lymphocytes from MS patiants are from low responder groups, in response to BORRELIA antigens MS patiants'T lymphocytes were proliferated more than normal controls. There was no statistically significant difference in PROLIFERATION RESPONSE to OspA and OspD between patients and controls.Considering the obtained results in this study and similar studies including an investigation in the year of 2000 for comparing the MS patients derived spirochets and lyme spirochets and a lot of similarities in pathogenesis and clinical manifestations of lyme and MS, as well as geographical overlap of MS and BORRELIA and association of MS and environmental factors it supposed that however the role of borrlia in MS pathogenesis is not completely confirmed but the spirochetal basis of MS cannot be simply rejected as well.Multiple factors like variability in Osps expression between BORRELIA specieses, and abundance of recombination in osps genes, are among the factors that can explain the obtained results.

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APA: Copy

RAHMANI, MANIZHEH, MOAZENI, S.M., & SANATI, M.H.. (2004). INVESTIGATION OF THE PROLIFERATION RESPONSE OF LYMPHOCYTES FROM MULTIPLE SCLEROSIS PATIENTS TO BORRELIA ANTIGENS. DANESHVAR MEDICINE, 11(48), 7-12. SID. https://sid.ir/paper/30601/en

Vancouver: Copy

RAHMANI MANIZHEH, MOAZENI S.M., SANATI M.H.. INVESTIGATION OF THE PROLIFERATION RESPONSE OF LYMPHOCYTES FROM MULTIPLE SCLEROSIS PATIENTS TO BORRELIA ANTIGENS. DANESHVAR MEDICINE[Internet]. 2004;11(48):7-12. Available from: https://sid.ir/paper/30601/en

IEEE: Copy

MANIZHEH RAHMANI, S.M. MOAZENI, and M.H. SANATI, “INVESTIGATION OF THE PROLIFERATION RESPONSE OF LYMPHOCYTES FROM MULTIPLE SCLEROSIS PATIENTS TO BORRELIA ANTIGENS,” DANESHVAR MEDICINE, vol. 11, no. 48, pp. 7–12, 2004, [Online]. Available: https://sid.ir/paper/30601/en

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