THE EFFECT OF MODIFIED CITRUS PECTIN (MCP) ON VIABILITY, MORPHOLOGY, AND CELL CYCLE ARREST OF DU-145 AND LNCAP PROSTATE CANCER CELL LINES

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TEHRANIAN NAJMEH; SEPEHRI HOURI; BIRAMIJAMAL FIROUZEH; MEHDIPOUR PARVIN; HOSSEIN NEZHAD ARASH; SARRAFNEJAD ABDOLFATTAH; HAJIZADEH EBRAHIM; DELPHI LADAN

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Journal: DANESHVAR MEDICINE Year:2011 | Volume:19 | Issue:95 Page(s): 65-78

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Title

THE EFFECT OF MODIFIED CITRUS PECTIN (MCP) ON VIABILITY, MORPHOLOGY, AND CELL CYCLE ARREST OF DU-145 AND LNCAP PROSTATE CANCER CELL LINES

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Keywords

PROSTATE CANCERQ2

DU-145 AND LNCAP CELL LINESQ2

CELL CYCLE ARRESTQ2

APOPTOSISQ2

PECTASOLQ1

DOXORUBICINQ1

Abstract

Background and Objective: This study was conducted to evaluate the effect of PECTASOL on modification of DOXORUBICIN (Dox) cytotoxicity and APOPTOSIS and cell cycle in PROSTATE CANCER cell lines (DU-145 & LNCaP)Materials and Methods: Human prostate carcinoma DU-145 AND LNCAP CELL LINES were treated with various concentrations of PECTASOL, Dox, or a combination of both.Cell viability was determined via the MTT assay and cell cycle progression was determined by flow cytometry using Flowmax Software.Results: DU-145 (androgen independent) cell lines were more sensitive than LNCaP (androgen dependent) cell lines.Combination of PECTASOL and Dox resulted in a 17.6% and 19.6% (p<0.001) decrease in the viability of the DU-145 and LNCaP cells. The IC50 values decreased 1.5 fold and 1.3 fold in the DU-145 and LNCaP cells, respectively. Treatment with both drugs led to an increase in Sub-G1 arrest (54.6% versus 12.2% in Dox) in DU-145. In LNCaP cells, combination of both drugs led to an increase in G2-M arrest (61.68% versus 53.56% in Dox).Conclusion: Based on our findings, the progressive cytotoxicity effect of Dox and PECTASOL together induce rapid cell death in DU-145 through APOPTOSIS and in LNCaP cells through CELL CYCLE ARREST (G2-M arrest).

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APA: Copy

TEHRANIAN, NAJMEH, SEPEHRI, HOURI, BIRAMIJAMAL, FIROUZEH, MEHDIPOUR, PARVIN, HOSSEIN NEZHAD, ARASH, SARRAFNEJAD, ABDOLFATTAH, HAJIZADEH, EBRAHIM, & DELPHI, LADAN. (2011). THE EFFECT OF MODIFIED CITRUS PECTIN (MCP) ON VIABILITY, MORPHOLOGY, AND CELL CYCLE ARREST OF DU-145 AND LNCAP PROSTATE CANCER CELL LINES. DANESHVAR MEDICINE, 19(95), 65-78. SID. https://sid.ir/paper/30627/en

Vancouver: Copy

TEHRANIAN NAJMEH, SEPEHRI HOURI, BIRAMIJAMAL FIROUZEH, MEHDIPOUR PARVIN, HOSSEIN NEZHAD ARASH, SARRAFNEJAD ABDOLFATTAH, HAJIZADEH EBRAHIM, DELPHI LADAN. THE EFFECT OF MODIFIED CITRUS PECTIN (MCP) ON VIABILITY, MORPHOLOGY, AND CELL CYCLE ARREST OF DU-145 AND LNCAP PROSTATE CANCER CELL LINES. DANESHVAR MEDICINE[Internet]. 2011;19(95):65-78. Available from: https://sid.ir/paper/30627/en

IEEE: Copy

NAJMEH TEHRANIAN, HOURI SEPEHRI, FIROUZEH BIRAMIJAMAL, PARVIN MEHDIPOUR, ARASH HOSSEIN NEZHAD, ABDOLFATTAH SARRAFNEJAD, EBRAHIM HAJIZADEH, and LADAN DELPHI, “THE EFFECT OF MODIFIED CITRUS PECTIN (MCP) ON VIABILITY, MORPHOLOGY, AND CELL CYCLE ARREST OF DU-145 AND LNCAP PROSTATE CANCER CELL LINES,” DANESHVAR MEDICINE, vol. 19, no. 95, pp. 65–78, 2011, [Online]. Available: https://sid.ir/paper/30627/en

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