Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats

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MOHEBBATI REZA; Bavarsad Kosar; RAHIMI MARYAM; Rakhshandeh Hasan; KHAJAVI RAD ABOLFAZL; SHAFEI MOHAMMAD NASER

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Journal: Avicenna Journal of Phytomedicine Year:2018 | Volume:8 | Issue:2 Page(s): 143-151

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Title

Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats

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Keywords

Ziziphus jujuba

Nitro-L-arginine methyl ester

Blood pressure

Hypertension

Nitric oxide

Abstract

Objective: Ziziphus jujuba stimulates the release of Nitric oxide (NO). Because NO is involved in cardiovascular regulations, in this study the effects of hydroalcoholic extract of Z. jujuba on cardiovascular responses in acute NG-Nitro-L-arginine methyl ester (L-NAME) hypertensive rats were evaluated. Materials and Methods: Rats were divided into 6 group (n=6): 1) saline, 2) L-NAME received (10mg/kg) intravenously, 3) sodium nitroprusside (SNP) (50μ g/kg)+L-NAME group received SNP before L-NAME and 4-6) three groups of Z. jujuba (100, 200 and 400mg/kg) that treated for four weeks and on the 28th day, L-NAME was injected. Femoral artery and vein were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic Blood pressure (SBP), Mean arterial pressure (MAP) and heart rate (HR) were recorded continuously. Maximal changes (Δ ) of SBP, MAP and HR were calculated and compared to control and L-NAME groups. Results: In L-NAME group, maximal Δ SBP (L-NAME: 44. 15± 4. 0 mmHg vs control: 0. 71± 2. 1 mmHg) and Δ MAP (L-NAME: 40. 8± 4. 0 mmHg vs control: 0. 57± 1. 6 mmHg) significantly increased (p<0. 001 in both) but Δ HR was not significant as compared to control (p>0. 05). All doses of Z. jujuba attenuated maximal Δ SBP and Δ MAP induced by L-NAME but only the lowest dose (100 mg/kg) had significant effects (Δ SBP: 20. 36± 5. 6 mmHg vs L-NAME: 44. 1± 4. 0 mmHg and Δ MAP: 20. 8± 4. 5 mmHg vs L-NAME: 40. 8± 3. 8 mmHg (p<0. 05 to p<0. 01)). The Δ HR at three doses was not significantly different from that of L-NAME group (p>0. 05). Conclusion: Because long-term consumption of Z. jujuba extract, especially its lowest dose, attenuated cardiovascular responses induced by L-NAME, we suggest that Z. jujuba has potential beneficial effects in prevention of Hypertension induced by NO deficiency.

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APA: Copy

MOHEBBATI, REZA, Bavarsad, Kosar, RAHIMI, MARYAM, Rakhshandeh, Hasan, KHAJAVI RAD, ABOLFAZL, & SHAFEI, MOHAMMAD NASER. (2018). Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(2), 143-151. SID. https://sid.ir/paper/326459/en

Vancouver: Copy

MOHEBBATI REZA, Bavarsad Kosar, RAHIMI MARYAM, Rakhshandeh Hasan, KHAJAVI RAD ABOLFAZL, SHAFEI MOHAMMAD NASER. Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(2):143-151. Available from: https://sid.ir/paper/326459/en

IEEE: Copy

REZA MOHEBBATI, Kosar Bavarsad, MARYAM RAHIMI, Hasan Rakhshandeh, ABOLFAZL KHAJAVI RAD, and MOHAMMAD NASER SHAFEI, “Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 2, pp. 143–151, 2018, [Online]. Available: https://sid.ir/paper/326459/en

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