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Information Journal Paper

Title

Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats

Pages

  347-361

Abstract

 Objective: Chronic hyperglycemia and overproduction of reactive oxygen species (ROS) are strong predictors of the development of reproductive complications of diabetes. The present study was conducted to determine the effects of Crocin on Biochemical parameters, oxidative stress, and Sperm characteristics as well as testes histopathology in diabetic rats. Materials and Methods: Twenty-four rats were divided into the four groups as follows: control, untreated diabetic and two Crocin (40 and 60 mg/kg/day)-treated diabetic groups. Diabetes was induced by injection of a single dose of Streptozotocin (STZ, 60 mg/kg). Administration of Crocin (intraperitoneally) was started three days after STZ injection and was continued until the 28 th day. At the end of the experiment, rats were anesthetized after weighing. Blood samples and epididymal sperm were subsequently collected to measure Biochemical parameters (glucose and lipid profile), total oxidant and antioxidant status (TOS and TAS, respectively), Oxidative stress index (OSI), and Sperm characteristics (count, motility, and viability); also, testes were dissected out for histopathology examination. Results: Our result indicated that blood glucose, cholesterol, triglyceride, LDL cholesterol levels, as well as TOS, and OSI decreased, but body weight, sperm counts, motility and viability, as well as TAS and HDL levels increased significantly in the Crocintreated diabetic rats (P˂ 0. 05). In testis sections from diabetic rats treated with Crocin (40 and 60 mg/kg), seminiferous tubules exhibited normal shape and restoration of testis architecture was observed. Conclusion: Administration of Crocin in the present study, ameliorated blood glucose, lipid abnormalities, oxidative stress, Sperm characteristics and testis damage in STZ-diabetic rats.

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References

Cite

APA: Copy

Sefidgar, Seyed Mersad, AHMADI HAMEDANI, MAHMOOD, JEBELLI JAVAN, ASHKAN, NARENJI SANI, REZA, & JAVAHERI VAYEGHAN, ABBAS. (2019). Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(4), 347-361. SID. https://sid.ir/paper/326523/en

Vancouver: Copy

Sefidgar Seyed Mersad, AHMADI HAMEDANI MAHMOOD, JEBELLI JAVAN ASHKAN, NARENJI SANI REZA, JAVAHERI VAYEGHAN ABBAS. Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(4):347-361. Available from: https://sid.ir/paper/326523/en

IEEE: Copy

Seyed Mersad Sefidgar, MAHMOOD AHMADI HAMEDANI, ASHKAN JEBELLI JAVAN, REZA NARENJI SANI, and ABBAS JAVAHERI VAYEGHAN, “Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 4, pp. 347–361, 2019, [Online]. Available: https://sid.ir/paper/326523/en

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