EFFECT OF PRETREATMENT BY NORADRENALINE AND ROLE α1 ADRENOCEPTOR AND MITOCHONDRIAL ATP SENSITIVE POTASSIUM CHANNEL ON CARDIAC ENZYMES IN ISCHEMIA/REPERFUSED HEART IN ANESTHETIZED RAT

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IMANI A.R.; FAGHIHI MAHDIEH; SADR S.SH.A.D.; SADEGHI NIARAKI SOMAYEH

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Journal: KOWSAR MEDICAL JOURNAL Year:2009 | Volume:13 | Issue:4 Page(s): 281-285

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Title

EFFECT OF PRETREATMENT BY NORADRENALINE AND ROLE α1 ADRENOCEPTOR AND MITOCHONDRIAL ATP SENSITIVE POTASSIUM CHANNEL ON CARDIAC ENZYMES IN ISCHEMIA/REPERFUSED HEART IN ANESTHETIZED RAT

Author(s)

IMANI A.R. | FAGHIHI MAHDIEH | SADR S.SH.A.D. | SADEGHI NIARAKI SOMAYEH | Issue Writer Certificate

Keywords

ISCHEMIA/REPERFUSIONQ3

NORADRENALINEQ3

CARDIAC ENZYMESQ3

Abstract

AIMS: NORADRENALINE protects myocardium against ISCHEMIA/REPERFUSION-induced infarction and arrhythmias via activation of a1-adrenoceptor and mitochondrial KATP channels (mKATP) in anesthetized rats. In present study we evaluated the effect of NORADRENALINE and role of a1-adrenoceptor and mKATP channel on plasma level of Lactate dehydrogenase (LDH) and Creatine kinase-MB (CKMB).METHODS: Anesthetized rats were subjected to 25 minutes regional ischaemia and 120 minutes reperfusion. In control group (n=9) saline was injected prior to ischemia. In IPC group (Ischemic Preconditioning; n=9) ischemia was preceded by three short episodes of ISCHEMIA/REPERFUSION. In group III (n=9), NORADRENALINE (2 mgr/kg) was injected prior to ischemia. In group IV (n=6), an a1-adrenoceptor blocker (prazosin, 0.5 mg/kg) was administrated prior to NORADRENALINE. In Groups V and VI (n=6), rats received 5-hydroxydecanoiate (5-HD; a specific mKATP channel inhibitor) prior to and after NORADRENALINE injection, respectively.RESULTS: IPC and NORADRENALINE markedly reduced plasma level of LDH and CKMB. Administration of prazosin or 5-HD suppressed effect of NORADRENALINE on LDH and CKMB.CONCLUSION: NORADRENALINE reduces plasma level of LDH and CKMB via activation of a1-adrenoceptor and mitochondrial KATP channel in anesthetized rat heart.

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APA: Copy

IMANI, A.R., FAGHIHI, MAHDIEH, SADR, S.SH.A.D., & SADEGHI NIARAKI, SOMAYEH. (2009). EFFECT OF PRETREATMENT BY NORADRENALINE AND ROLE α₁ ADRENOCEPTOR AND MITOCHONDRIAL ATP SENSITIVE POTASSIUM CHANNEL ON CARDIAC ENZYMES IN ISCHEMIA/REPERFUSED HEART IN ANESTHETIZED RAT. KOWSAR MEDICAL JOURNAL, 13(4), 281-285. SID. https://sid.ir/paper/32889/en

Vancouver: Copy

IMANI A.R., FAGHIHI MAHDIEH, SADR S.SH.A.D., SADEGHI NIARAKI SOMAYEH. EFFECT OF PRETREATMENT BY NORADRENALINE AND ROLE α₁ ADRENOCEPTOR AND MITOCHONDRIAL ATP SENSITIVE POTASSIUM CHANNEL ON CARDIAC ENZYMES IN ISCHEMIA/REPERFUSED HEART IN ANESTHETIZED RAT. KOWSAR MEDICAL JOURNAL[Internet]. 2009;13(4):281-285. Available from: https://sid.ir/paper/32889/en

IEEE: Copy

A.R. IMANI, MAHDIEH FAGHIHI, S.SH.A.D. SADR, and SOMAYEH SADEGHI NIARAKI, “EFFECT OF PRETREATMENT BY NORADRENALINE AND ROLE α₁ ADRENOCEPTOR AND MITOCHONDRIAL ATP SENSITIVE POTASSIUM CHANNEL ON CARDIAC ENZYMES IN ISCHEMIA/REPERFUSED HEART IN ANESTHETIZED RAT,” KOWSAR MEDICAL JOURNAL, vol. 13, no. 4, pp. 281–285, 2009, [Online]. Available: https://sid.ir/paper/32889/en

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