NEOSTIGMINE FOR THE TREATMENT OF ACUTE COLONIC PSEUDO -OBSTRUCTION IN PATIENTS WITH ABDOMINAL SURGERY

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FANAEI S.A.; MOHEBI HASAN ALI; MORADI MEHRAN

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Journal: KOWSAR MEDICAL JOURNAL Year:2008 | Volume:12 | Issue:4 Page(s): 331-359

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Title

NEOSTIGMINE FOR THE TREATMENT OF ACUTE COLONIC PSEUDO -OBSTRUCTION IN PATIENTS WITH ABDOMINAL SURGERY

Author(s)

FANAEI S.A. | MOHEBI HASAN ALI | MORADI MEHRAN | Issue Writer Certificate

Keywords

NEOSTIGMINEQ3

COLONIC PSEUDO-OBSTRUCTIONQ2

AUTONOMIC NERVEQ3

Abstract

Background: COLONIC PSEUDO-OBSTRUCTION is a poorly understood syndrome, described byOgilvie, and characterized by signs of large-bowel obstruction, without a mechanical cause. An imbalance in the AUTONOMIC NERVE supply to the colon has been suggested as the pathophysiology. Recently, promising results with pharmacologic manipulation with NEOSTIGMINE have been described.Study Design: A prospective study was undertaken with 42 consecutive patients with clinical and radiologic signs of COLONIC PSEUDO-OBSTRUCTION, in two general hospitals, over a 2-year period. Patients divided in two groups (21 patients in each group) then NEOSTIGMINE group were treated primarily with 2.5 mg of NEOSTIGMINE in 250 mL of saline for 30 minutes under cardiac monitoring. Results were assessed by the clinical and radiologic responses.Results: 20 patients in NEOSTIGMINE group had gas passing and defication with the firs dose of NEOSTIGMINE but none of the patients in control group had gas passing and defication (P=0.000). The mean (±SD) abdominal distension in NEOSTIGMINE group was 121.42±17.13 vs 128.38±16.7 in control group before treatment (P>0.05) that it reached to 100.85±14.61 and 124±16.15 respectively in NEOSTIGMINE and control group after 3 hours of beginning treatment (P=0.000).Conclusions: NEOSTIGMINE is a simple, safe, and effective therapy for treatment of COLONIC PSEUDO-OBSTRUCTION.

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APA: Copy

FANAEI, S.A., MOHEBI, HASAN ALI, & MORADI, MEHRAN. (2008). NEOSTIGMINE FOR THE TREATMENT OF ACUTE COLONIC PSEUDO -OBSTRUCTION IN PATIENTS WITH ABDOMINAL SURGERY. KOWSAR MEDICAL JOURNAL, 12(4), 331-359. SID. https://sid.ir/paper/33017/en

Vancouver: Copy

FANAEI S.A., MOHEBI HASAN ALI, MORADI MEHRAN. NEOSTIGMINE FOR THE TREATMENT OF ACUTE COLONIC PSEUDO -OBSTRUCTION IN PATIENTS WITH ABDOMINAL SURGERY. KOWSAR MEDICAL JOURNAL[Internet]. 2008;12(4):331-359. Available from: https://sid.ir/paper/33017/en

IEEE: Copy

S.A. FANAEI, HASAN ALI MOHEBI, and MEHRAN MORADI, “NEOSTIGMINE FOR THE TREATMENT OF ACUTE COLONIC PSEUDO -OBSTRUCTION IN PATIENTS WITH ABDOMINAL SURGERY,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 4, pp. 331–359, 2008, [Online]. Available: https://sid.ir/paper/33017/en

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