Study of Codon 72 Polymorphism of TP53 Gene in Cervical Biopsies with Abnormal Histology in Bushehr Province

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAKER ALHOSSEINI M.; NAEIMI S.; MORADINASAB M.; TAHERKHANI S.; FARSHADPOUR F.; ANSARIFAR A.; TAHERKHANI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2018 | Volume:21 | Issue:1 Page(s): 19-28

Download Full-Text

Persian Verion

View:

521

Download:

Cites:

Information Journal Paper

Title

Study of Codon 72 Polymorphism of TP53 Gene in Cervical Biopsies with Abnormal Histology in Bushehr Province

Author(s)

Keywords

PolymorphismQ2

TP53 geneQ1

Herpes simplex virusQ2

Allele-specific PCRQ2

Abstract

Background: TP53 tumor suppressor gene play a role in repairing DNA damages and also in cell apoptosis. This research have paid to the association between codon 72 Polymorphism of TP53 gene in a variety of abnormal cervical tissue samples compared to samples of healthy women as a control group and also frequency of human Herpes simplex viruses (HSV) in these samples. Material and Methods: In this case-control study, 110 biopsies of the cervix with abnormal pathology were examined from archives of the Department of Pathology at Shohadaye Khalij Fars Hospital, and 164 healthy women were selected as control group. PCR test was used for detection of HSV, and Allele-specific PCR was used for analysis of codon 72 Polymorphism of TP53 gene. Data was analyzed with SPSS software. Results: Distribution of codon 72 of TP53 genotypes in patient and control groups was not statistically significant. Evaluation of the frequency of arginine and proline alleles in patient and control groups revealed that those without proline allele were lower in patients (19%) compared to controls (30. 1%), and this difference was statistically significant (p=0. 04), (OR: 1. 03-3. 36, CI 95%=1. 86). Also there were not significant correlation between the various results of pathology, age, ethnicity and place of residence with the TP53 genotype. In this study, HSV was not detected in samples. Conclusion: Because of significant difference in proline allele between the case and control groups, it seems that this allele is associated with the abnormal cervical pathology results in Bushehr province.

Cites

No record.

References

No record.

Cite

APA: Copy

ZAKER ALHOSSEINI, M., NAEIMI, S., MORADINASAB, M., TAHERKHANI, S., FARSHADPOUR, F., ANSARIFAR, A., & TAHERKHANI, R.. (2018). Study of Codon 72 Polymorphism of TP53 Gene in Cervical Biopsies with Abnormal Histology in Bushehr Province. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 21(1 ), 19-28. SID. https://sid.ir/paper/33459/en

Vancouver: Copy

ZAKER ALHOSSEINI M., NAEIMI S., MORADINASAB M., TAHERKHANI S., FARSHADPOUR F., ANSARIFAR A., TAHERKHANI R.. Study of Codon 72 Polymorphism of TP53 Gene in Cervical Biopsies with Abnormal Histology in Bushehr Province. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2018;21(1 ):19-28. Available from: https://sid.ir/paper/33459/en

IEEE: Copy

M. ZAKER ALHOSSEINI, S. NAEIMI, M. MORADINASAB, S. TAHERKHANI, F. FARSHADPOUR, A. ANSARIFAR, and R. TAHERKHANI, “Study of Codon 72 Polymorphism of TP53 Gene in Cervical Biopsies with Abnormal Histology in Bushehr Province,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 21, no. 1 , pp. 19–28, 2018, [Online]. Available: https://sid.ir/paper/33459/en

Related Journal Papers