METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN

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TABATABAEI S.M.; ABDOLLAH SHAMSHIRSAZ A.; BAKHIRNIA M.R.; KAMGHAR M.; BOZARI N.; POURZAHED GILANI N.; KOMILIAN Z.; HABIBZADEH M.R.; ABDOLLAH SHAMSHIRSAZ A.H.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2002 | Volume:5 | Issue:1 Page(s): 63-72

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Title

METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN

Author(s)

Keywords

HYPOTHYROIDISMQ3

THALASSEMIAQ3

OSTEOPOROSISQ3

HYPOGONADISMQ2

PUBERTYQ4

HYPOPARATHYROIDISMQ4

Abstract

Objectives: The combination of transfusion and chelation therapy has dramatically extended the life expectancy of thalassemic patients. The main objective of this study is to determine the prevalence of prominent metabolic and en docrinologic complications in beta-thalassemia major.Methods: A total of 220 patients entered the study. Physicians collected demographic data and the history of therapies. Serum levels of 25(OH)D, calcium, phosphate, iPTH were measured. Thyroid function was assessed by T3, T4 and TSH. Zinc and copper in serum were determined by flame atomic absorption spectrophotometry. Bone mineral density (BMD) measurements at lumbar and femoral regions have been done using dual x-ray absorptiometry. The dietary calcium, zinc and copper intakes were estimated by food-frequency questionnaires.Results: Short stature was seen in 39.3% of our patients HYPOGONADISM was seen in 22.9% of boys and 12.2% of girls. HYPOPARATHYROIDISM and primary HYPOTHYROIDISM were present in 7.6% and 7.7% of the patients, respectively. About 13 % of patients had more than one endocrine complication with mean serum ferritin of 1678±955 µg/lit. Prevalence of lumbar OSTEOPOROSIS and osteopenia were 50.7% and 39.4%; respectively. Femoral osteopororsis and osteopenia were present in 10.8% and 36.9% of the patients. Lumbar BMD abnormalities were associated with duration of chelation theray. Low serum zinc and copper was observed in 79.6% and 68% of the study population, respectively. Serum zinc showed significant association with lumbar but not femoral BMD. In 37.2% of patients serum levels of 25(OH)D below 23 nmol/I were detected.Conclusion: High prevalence of complications among our thalassemic patients signifies the importance of planning more detailed studies along with therapeutic interventions.

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شیوع کمبود روی در دانش آموزان مدارس راهنمایی شهر تهران

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APA: Copy

TABATABAEI, S.M., ABDOLLAH SHAMSHIRSAZ, A., BAKHIRNIA, M.R., KAMGHAR, M., BOZARI, N., POURZAHED GILANI, N., KOMILIAN, Z., HABIBZADEH, M.R., ABDOLLAH SHAMSHIRSAZ, A.H., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2002). METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 5(1), 63-72. SID. https://sid.ir/paper/34124/en

Vancouver: Copy

TABATABAEI S.M., ABDOLLAH SHAMSHIRSAZ A., BAKHIRNIA M.R., KAMGHAR M., BOZARI N., POURZAHED GILANI N., KOMILIAN Z., HABIBZADEH M.R., ABDOLLAH SHAMSHIRSAZ A.H., ARDESHIR LARIJANI MOHAMMAD BAGHER. METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2002;5(1):63-72. Available from: https://sid.ir/paper/34124/en

IEEE: Copy

S.M. TABATABAEI, A. ABDOLLAH SHAMSHIRSAZ, M.R. BAKHIRNIA, M. KAMGHAR, N. BOZARI, N. POURZAHED GILANI, Z. KOMILIAN, M.R. HABIBZADEH, A.H. ABDOLLAH SHAMSHIRSAZ, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 5, no. 1, pp. 63–72, 2002, [Online]. Available: https://sid.ir/paper/34124/en

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