ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR

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MOSTAFAVI H.; AFKHAMIZADEH M.; REZVANFAR M.R.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2005 | Volume:7 | Issue:2 (SN 26) Page(s): 143-147

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Information Journal Paper

Title

ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR

Author(s)

MOSTAFAVI H. | AFKHAMIZADEH M. | REZVANFAR M.R. | Issue Writer Certificate

Keywords

THALASSEMIA MAJORQ3

ENDOCRINE DISORDERSQ4

HYPOGONADISMQ3

GROWTH RETARDQ3

PUBERTYQ4

DIABETESQ3

HYPOCALCEMIAQ3

HYPOTHYROIDISMQ4

Abstract

Introduction: THALASSEMIA MAJOR, as hemolytic disorder leads to increased iron load in patients and despite current treatment with deferouxamine the precipitation of iron in different endocrine systems results in disturbances in theses endocrine systems. In this study we evaluated ENDOCRINE DISORDERS in patients with THALASSEMIA MAJOR. Materials and Methods: Subjects were patients with THALASSEMIA MAJOR who referred to the endocrinology clinic. All of them underwent thyroid function tests and biochemistry assays. Growth hormone stimulation with levodopa, was done if indicated. FSH and LH, stradiol and testosterone were requested for adolescents. Results: 44 patients 8.5 to 25 years old underwent all tests. 40.9% of them were female. 11.3% of them had DIABETES, and 88% of adolescents had hypogonadotropic HYPOGONADISM. 15.9% had HYPOCALCEMIA and hyperphosphatemia. None of them had thyroid disorders. Height of 90.9%of patients was under the fifth percentile. Only 22.2% had abnormal response to stimulation test with levodopa. 22.7% of patients had normal results for endocrine tests. Conclusion: Our result showed that despite deferoxamine treatment in our patients, THALASSEMIA MAJOR ENDOCRINE DISORDERS were common. Hence, more effective treatment with deferoxamine appropriate dose and time of initiation is recommended.

Cites

References

METABOLIC AND ENDOCRINOLOGIC COMPLICATIONS IN BETA-THALASSEMIA MAJOR: A MULTICENTER STUDY IN TEHRAN

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APA: Copy

MOSTAFAVI, H., AFKHAMIZADEH, M., & REZVANFAR, M.R.. (2005). ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 7(2 (SN 26)), 143-147. SID. https://sid.ir/paper/27868/en

Vancouver: Copy

MOSTAFAVI H., AFKHAMIZADEH M., REZVANFAR M.R.. ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;7(2 (SN 26)):143-147. Available from: https://sid.ir/paper/27868/en

IEEE: Copy

H. MOSTAFAVI, M. AFKHAMIZADEH, and M.R. REZVANFAR, “ENDOCRINE DISORDERS IN PATIENTS WITH THALASSEMIA MAJOR,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 7, no. 2 (SN 26), pp. 143–147, 2005, [Online]. Available: https://sid.ir/paper/27868/en

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