EFFECT OF RESVERATROL THE EXPRESSION OF SOME GENES INVOLVED EPIGENETIC IN BREAST CANCER CELL LINES (MCF-7, MDA-MB-453)

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AHMADIRAD HADIS; HAJIZADEH MOHAMMAD REZA; MAHMOODI MEHDI; MIRZAEE MOHAMADREZA; MOHAMMADIAN SHAHRBABAKI FAHIME; Soltaninejad Mostafa

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:7 Page(s): 526-536

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Title

EFFECT OF RESVERATROL THE EXPRESSION OF SOME GENES INVOLVED EPIGENETIC IN BREAST CANCER CELL LINES (MCF-7, MDA-MB-453)

Author(s)

Keywords

RESVERATROLQ1

GENE EXPRESSIONQ2

EPIGENETICSQ2

CELL LINESQ1

BREAST CANCERQ2

MCF-7Q2

MDA-MB-453Q2

Abstract

Introduction: BREAST CANCER is one of the most common cancers among women. The wrong pattern GENE EXPRESSION involved in Epigenetic such asAPOBEC3B, DNMT-1 and TET-1 can cause the progress breath cancer.According to the previous studies, RESVERATROL is a natural Flavonoid, which has recent studies have shown antioxidant and anti-cancer properties.Methods: In this study, the effect of 25 and 100 μM concentrations of RESVERATROL on two types of cell line (MCF-7, MDA-MB-453) was investigated. Then, after 24 hours treatment of cells, mRNA was extracted and turned to cDNA. Finally, genes expression of APOBEC3B, DNMT-1 and TET-1 were determined by Real time technique.Results: The results showed that RESVERATROL decreased APOBEC3B and DNMT-1 GENE EXPRESSION but TET-1 GENE EXPRESSION was increased following threatment By RESVERATROL in both CELL LINES compared to the to the control group and it also increased in expression of TET-1 in both of CELL LINES compared with the control group.Discussion: Considering the satisfactory effects of RESVERATROL after 24 hours of treatment on BREAST CANCER cells, its anticancer effects are likely to be exerted through epigenetic changes, although more definitive studies are needed.

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APA: Copy

AHMADIRAD, HADIS, HAJIZADEH, MOHAMMAD REZA, MAHMOODI, MEHDI, MIRZAEE, MOHAMADREZA, MOHAMMADIAN SHAHRBABAKI, FAHIME, & Soltaninejad, Mostafa. (2017). EFFECT OF RESVERATROL THE EXPRESSION OF SOME GENES INVOLVED EPIGENETIC IN BREAST CANCER CELL LINES (MCF-7, MDA-MB-453). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(7 ), 526-536. SID. https://sid.ir/paper/35752/en

Vancouver: Copy

AHMADIRAD HADIS, HAJIZADEH MOHAMMAD REZA, MAHMOODI MEHDI, MIRZAEE MOHAMADREZA, MOHAMMADIAN SHAHRBABAKI FAHIME, Soltaninejad Mostafa. EFFECT OF RESVERATROL THE EXPRESSION OF SOME GENES INVOLVED EPIGENETIC IN BREAST CANCER CELL LINES (MCF-7, MDA-MB-453). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(7 ):526-536. Available from: https://sid.ir/paper/35752/en

IEEE: Copy

HADIS AHMADIRAD, MOHAMMAD REZA HAJIZADEH, MEHDI MAHMOODI, MOHAMADREZA MIRZAEE, FAHIME MOHAMMADIAN SHAHRBABAKI, and Mostafa Soltaninejad, “EFFECT OF RESVERATROL THE EXPRESSION OF SOME GENES INVOLVED EPIGENETIC IN BREAST CANCER CELL LINES (MCF-7, MDA-MB-453),” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 7 , pp. 526–536, 2017, [Online]. Available: https://sid.ir/paper/35752/en

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