Genotypic Investigation of Methicillin Resistant Staphylococcus aureus Strains Isolated from Urinary Tract Infection

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SAEDI SAMIRA; DERAKHSHAN SAFOURA; GHADERI EBRAHIM; SALAVATI SAEED

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:29 | Issue:181 Page(s): 26-38

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Title

Genotypic Investigation of Methicillin Resistant Staphylococcus aureus Strains Isolated from Urinary Tract Infection

Author(s)

SAEDI SAMIRA | DERAKHSHAN SAFOURA | GHADERI EBRAHIM | SALAVATI SAEED | Issue Writer Certificate

Keywords

drug resistanceQ2

Staphylococcus aureusQ2

urinary tractQ2

MecA proteinQ1

Abstract

Background and purpose: Methicillin resistant Staphylococcus aureus (MRSA) have recently emerged as major causes of urinary tract infection (UTI). The aims of this study were to determine antibiotic susceptibility of S. aureus isolated from UTI and to detect the presence of mecA (causing resistance to methicillin) and SCCmec types. Materials and methods: In this cross sectional study, 44 S. aureus isolates were collected in autumn 2017 from patients with UTI in two hospitals in Sanandaj, west of Iran. Susceptibility rates to nine antibiotics and vancomycin were determined by disk diffusion method and E test, respectively. The mecA and SCCmec types were detected by polymerase chain reaction (PCR). Descriptive statistics were used to evaluate the data. Results: Vancomycin, linezolid, and trimethoprim-sulfamethoxazole showed the highest susceptibility rates (more than 90%), followed by gentamicin (86. 4%), cefoxitin (79. 5%), tetracycline (77. 3%), clindamycin (75%), ciprofloxacin (70. 4%), erythromycin (52. 3%), and penicillin (6. 8%). The isolates from inpatients were more susceptible to antibiotics compared to those from outpatients. Of the 44 isolates, 9 (20. 5%) were MRSA, of which 6 were isolated from outpatients. Five of 9 MRSA isolates carried the mecA gene, and of these, two isolates harbored SCCmec V while three were nontypeable. Conclusion: Our study suggests that trimethoprim-sulfamethoxazole, vancomycin or linezolid would be suitable agents in treatment of UTI caused by MRSA. Identification of an MRSA isolate in urine is a serious concern and highlights the need for monitoring drug resistance in S. aureus.

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APA: Copy

SAEDI, SAMIRA, DERAKHSHAN, SAFOURA, GHADERI, EBRAHIM, & SALAVATI, SAEED. (2020). Genotypic Investigation of Methicillin Resistant Staphylococcus aureus Strains Isolated from Urinary Tract Infection. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(181 ), 26-38. SID. https://sid.ir/paper/362888/en

Vancouver: Copy

SAEDI SAMIRA, DERAKHSHAN SAFOURA, GHADERI EBRAHIM, SALAVATI SAEED. Genotypic Investigation of Methicillin Resistant Staphylococcus aureus Strains Isolated from Urinary Tract Infection. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(181 ):26-38. Available from: https://sid.ir/paper/362888/en

IEEE: Copy

SAMIRA SAEDI, SAFOURA DERAKHSHAN, EBRAHIM GHADERI, and SAEED SALAVATI, “Genotypic Investigation of Methicillin Resistant Staphylococcus aureus Strains Isolated from Urinary Tract Infection,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 181 , pp. 26–38, 2020, [Online]. Available: https://sid.ir/paper/362888/en

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