EFFECTS OF ACHILLEA MILLEFOLIUM ON THE CONSEQUENCES OF STROKE IN OVARECTOMIZED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IMANI E.; ESMAILI A.; ALIMOHAMMADI R.; EHSANI V.; SHAMSIZADEH A.; MOBINI M.; REZAZADEH H.; NADERI S.; TAVAKOLI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2015 | Volume:22 | Issue:6 Page(s): 1725-1736

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,180

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF ACHILLEA MILLEFOLIUM ON THE CONSEQUENCES OF STROKE IN OVARECTOMIZED RATS

Author(s)

Keywords

ACHILLEA MILLEFOLIUMQ2

CEREBRAL ISCHEMIAQ3

ESTROGENQ2

OVARIECTOMYQ2

RATQ2

Abstract

Introduction: Previous studies indicated ESTROGEN as a protective factor in brain cells. In this study, effect of Yarrow extract (ACHILLEA MILLEFOLIUM), containing a phytoestrogen, were examined on the consequences of stroke in the middle cerebral artery occlusion model in ovariectomized female RATs.Methods: In the present study, 32 female Wistar RATs weighing 200 to 250 g were randomly divided into 4 groups which included: sham, control (ovariectomized- stroke induced), yarrow (ovariectomized, gavage ACHILLEA MILLEFOLIUM extract dose 500mg/kg and 50mg/kg for a month was given orally to animals). After surgery, infarction volume was measured a week after stroke. Moreover, sensorimotor disorder using paper labels (Sticky test) and neurological disorder via Bederson test at 24, 48 h, and a week after induction of stroke were tested and compared.Results: The results of the current study demonstrated that ACHILLEA MILLEFOLIUM extract with 500 mg/kg dose significantly reduced infarction volume a week after stroke (p<0.01), and sensorimotor disorder (sticky) at 24, 48 hours and a week after stroke, respectively. Furthermore, neurological disorders reduced at 24 and 48 hours (p<0.001) and week (p<0.01) after stroke compared to the control groups. On the other hand, ACHILLEA MILLEFOLIUM extract with 50o mg/kg dose reduced infarct volume, neurological and sensorimotor disorders, though this reduction was not statistically significant.Conclusion: The study findings revealed that oral administration of ACHILLEA MILLEFOLIUM extract with dose of 500mg/kg in ovariectomized female RATs caused a significant reduction in infarct volume, neurological disorders and sensorimotor disorder after middle cerebral artery occlusion.

Cites

References

No record.

Cite

APA: Copy

IMANI, E., ESMAILI, A., ALIMOHAMMADI, R., EHSANI, V., SHAMSIZADEH, A., MOBINI, M., REZAZADEH, H., NADERI, S., & TAVAKOLI, M.. (2015). EFFECTS OF ACHILLEA MILLEFOLIUM ON THE CONSEQUENCES OF STROKE IN OVARECTOMIZED RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 22(6), 1725-1736. SID. https://sid.ir/paper/36322/en

Vancouver: Copy

IMANI E., ESMAILI A., ALIMOHAMMADI R., EHSANI V., SHAMSIZADEH A., MOBINI M., REZAZADEH H., NADERI S., TAVAKOLI M.. EFFECTS OF ACHILLEA MILLEFOLIUM ON THE CONSEQUENCES OF STROKE IN OVARECTOMIZED RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(6):1725-1736. Available from: https://sid.ir/paper/36322/en

IEEE: Copy

E. IMANI, A. ESMAILI, R. ALIMOHAMMADI, V. EHSANI, A. SHAMSIZADEH, M. MOBINI, H. REZAZADEH, S. NADERI, and M. TAVAKOLI, “EFFECTS OF ACHILLEA MILLEFOLIUM ON THE CONSEQUENCES OF STROKE IN OVARECTOMIZED RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 6, pp. 1725–1736, 2015, [Online]. Available: https://sid.ir/paper/36322/en

Related Journal Papers