THE EFFECT OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON BLOOD- BRAIN BARRIER PERMEABILITY AND NEUROMOTOR DEFICITS IN MALE RAT TRANSIENT ISCHEMIC MODEL

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GHASEMLOU E.; RAHNEMA M.; BIGDELI M.R.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2016 | Volume:15 | Issue:2 Page(s): 139-150

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON BLOOD- BRAIN BARRIER PERMEABILITY AND NEUROMOTOR DEFICITS IN MALE RAT TRANSIENT ISCHEMIC MODEL

Author(s)

GHASEMLOU E. | RAHNEMA M. | BIGDELI M.R. | Issue Writer Certificate

Keywords

SALVIA OFFICINALISQ2

TRANSIENT ISCHEMIAQ1

BLOOD BRAIN BARRIER PERMEABILITYQ1

NEUROLOGIC DEFICITSQ2

Abstract

Background and Objectives: In the early stages of brain ischemia, the production of free radicals increases. SALVIA OFFICINALIS is a rich source of antioxidant compounds. Therefore, in this study the effects of hydroalcoholic extract of SALVIA OFFICINALIS on blood-brain barrier permeability and neurological deficits have been studied.Materials and Methods: In this experimental study 35 male Wistar rats were randomly divided into 5 groups of 7 rats. The control group received distilled water; three groups received hydroalcoholic extracts of SALVIA OFFICINALIS, respectively with doses of 50, 75 and 100 mg/kg for, 3 weeks intraperitoneally; The sham group was not treated and was not induced bybrain ischemia. Thereafter, the first four groups underwent middle cerebral artery occlusion 2 hours after the last injection and were induced by focal cerebral ischemia model, then blood- brain barrier permeability, and NEUROLOGIC DEFICITS were investigated. Data were analyzed using one-way ANOVA.Results: The hydroalcoholic extract of salvia could reduce permeability of the blood-brain barrier in three doses of 50 (10.68±0.54), 75 (5.87±0.41), and 100 mg/kg (5.19±0.49) compared with the control group (p=0.018, p<0.001 and p<0.001, respectively). NEUROLOGIC DEFICITS reduced in the experimental groups of 75 and 100 mg/kg (p=0.017, p=0.002, respectively) compared with the control group.Conclusion: These results indicate that SALVIA OFFICINALIS can make a guardianship in front of brain ischemia because it reduces blood- brain barrier permeability and NEUROLOGIC DEFICITS.

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APA: Copy

GHASEMLOU, E., RAHNEMA, M., & BIGDELI, M.R.. (2016). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON BLOOD- BRAIN BARRIER PERMEABILITY AND NEUROMOTOR DEFICITS IN MALE RAT TRANSIENT ISCHEMIC MODEL. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 15(2), 139-150. SID. https://sid.ir/paper/70880/en

Vancouver: Copy

GHASEMLOU E., RAHNEMA M., BIGDELI M.R.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON BLOOD- BRAIN BARRIER PERMEABILITY AND NEUROMOTOR DEFICITS IN MALE RAT TRANSIENT ISCHEMIC MODEL. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2016;15(2):139-150. Available from: https://sid.ir/paper/70880/en

IEEE: Copy

E. GHASEMLOU, M. RAHNEMA, and M.R. BIGDELI, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF SALVIA OFFICINALIS ON BLOOD- BRAIN BARRIER PERMEABILITY AND NEUROMOTOR DEFICITS IN MALE RAT TRANSIENT ISCHEMIC MODEL,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 15, no. 2, pp. 139–150, 2016, [Online]. Available: https://sid.ir/paper/70880/en

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