The effect of 14 weeks of endurance training with two different Intensity on serum irisin level, gene expression of skeletal muscle PGC1-α and FNDC5 and subcutaneous adipose tissue UCP1 in obese rats

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Ghaderi Mahbanou; MOHEBBI HAMID; SOLTANI BAHRAM

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:41 | Issue:1 Page(s): 72-81

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Title

The effect of 14 weeks of endurance training with two different Intensity on serum irisin level, gene expression of skeletal muscle PGC1-α and FNDC5 and subcutaneous adipose tissue UCP1 in obese rats

Author(s)

Ghaderi Mahbanou | MOHEBBI HAMID | SOLTANI BAHRAM | Issue Writer Certificate

Keywords

Exercise trainingQ1

FNDC5 proteinQ1

Peroxisome proliferator-activated receptor gamma coactivator1-alphaQ1

Uncoupling protein 1Q1

Abstract

Background: Irisin is a new myokine that has a beneficial effects of exercise on energy metabolism. However, irisin response to different intensities of endurance training is not completely understood. Methods: In the current experimental study, 18 male Wistar rats were fed a high-fat diet and 6 rats were nourished a standard diet for 12 weeks. After 12 weeks, obese rats were randomly divided into 3 groups: high-intensity training (34 m/min ~85% VO2max), moderate-intensity training (28 m/min ~70% VO2max) and control. Exercise groups trained 5 days/week for 12 weeks on a rodent treadmill. Serum irisin level and gene expression changes were measured using ELISA and Real Time-PCR method, respectively. Results: In high and moderate-intensity endurance training expression of PGC1-α (P=0. 001 and P=0. 001), FNDC5 (P=0. 013 and P=0. 049) and UCP1 (P=0. 001 and P=0. 001) were significantly more than the control group. Serum irisin level only after high-intensity training was more than the control group (P=0. 014). A positive correlation was observed between serum irisin and UCP1 in both of high (P=0. 017) and moderate-intensity (P=0. 046) training groups. Conclusion: High-intensity endurance training has a positive effect on the level of serum irisin. Also, there is a positive correlation between irisin and UCP1 gene expression in subcutaneous adipose tissue. However, irisin isn’ t the only factor affecting on exercise-induced UCP1 gene expression.

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References

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

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APA: Copy

Ghaderi, Mahbanou, MOHEBBI, HAMID, & SOLTANI, BAHRAM. (2019). The effect of 14 weeks of endurance training with two different Intensity on serum irisin level, gene expression of skeletal muscle PGC1-α and FNDC5 and subcutaneous adipose tissue UCP1 in obese rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(1 ), 72-81. SID. https://sid.ir/paper/364751/en

Vancouver: Copy

Ghaderi Mahbanou, MOHEBBI HAMID, SOLTANI BAHRAM. The effect of 14 weeks of endurance training with two different Intensity on serum irisin level, gene expression of skeletal muscle PGC1-α and FNDC5 and subcutaneous adipose tissue UCP1 in obese rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(1 ):72-81. Available from: https://sid.ir/paper/364751/en

IEEE: Copy

Mahbanou Ghaderi, HAMID MOHEBBI, and BAHRAM SOLTANI, “The effect of 14 weeks of endurance training with two different Intensity on serum irisin level, gene expression of skeletal muscle PGC1-α and FNDC5 and subcutaneous adipose tissue UCP1 in obese rats,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 1 , pp. 72–81, 2019, [Online]. Available: https://sid.ir/paper/364751/en

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