Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet

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Mostafavian Maryam; ABDI AHMAD; MEHRABANI JAVAD; BARARI ALIREZA

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Journal: Complementary Medicine Journal Year:2020 | Volume:10 | Issue:2 (35) Page(s): 106-117

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Information Journal Paper

Title

Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet

Author(s)

Mostafavian Maryam | ABDI AHMAD | MEHRABANI JAVAD | BARARI ALIREZA | Issue Writer Certificate

Keywords

ExerciseQ1

CapsaicinQ1

DietQ1

High-fatQ1

Brown adipose tissueQ1

Abstract

Objective Decreased physical activity coupled with increased High‐ Fat Diet (HFD) intake prompts obesity. Current research suggests that changing White Adipose Tissue (WAT) to brown promotes energy expenditure to counter obesity. The purpose of this study was to investigate the effects of aerobic Progressive training and Capsaicin (Cap) on Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha (PGC-1α ) and Uncoupling protein-1 (UPC-1) gene expression in rat fed a High-fat Diet. Methods 40 male Wistar rats aged 8-12 weeks, were fed a Normal Diet (ND) (n=8) or HFD (n=32) for 8 weeks. After 8 weeks, rats were divided into 5 groups: ND, HFD, High-fat Diet-Training (HFDT), High-fat Diet-Capsaicin (HFDCap), High-fat Diet-Training-Capsaicin (HFDTCap). Training groups have performed a progressive aerobic running program on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/ day) were administered orally, by gavage, once a day. PGC-1α and UCP-1 gene expression levels in the VAT were measured by Real-time PCR method. Results The results of this study showed that PGC-1α and UCP-expression was decreased in HFD group compared to ND group. Also, the expression of PGC-1α and UPC-1 in HFDT, HFDCap and HFDTCap groups was significantly increased compared to HFD. The expression of PGC-1α and UPC-1 in HFDTCap was also significantly increased compared to HFDT and HFDCap groups. Conclusion Possibly, eight weeks of progressive training combined with Capsaicin administration has an effect on the browning of visceral adipose tissue in HFD rats by increasing expression of PGC-1α and UCP-1...

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APA: Copy

Mostafavian, Maryam, ABDI, AHMAD, MEHRABANI, JAVAD, & BARARI, ALIREZA. (2020). Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 10(2 (35) ), 106-117. SID. https://sid.ir/paper/416281/en

Vancouver: Copy

Mostafavian Maryam, ABDI AHMAD, MEHRABANI JAVAD, BARARI ALIREZA. Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2020;10(2 (35) ):106-117. Available from: https://sid.ir/paper/416281/en

IEEE: Copy

Maryam Mostafavian, AHMAD ABDI, JAVAD MEHRABANI, and ALIREZA BARARI, “Effect of Eight Weeks of Aerobic Progressive Training with Capsaicin on Changes in PGC-1α and UPC-1 Expression in Visceral Adipose Tissue of Obese Rats With Diet,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 10, no. 2 (35) , pp. 106–117, 2020, [Online]. Available: https://sid.ir/paper/416281/en

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