SURVEY ON CCR5-Δ32 MUTATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH CHRONIC HEPATITIS B REFERRED TO THE CLINICAL LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION

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JALALI SAJJAD; SHARIFI ZOHREH; SANATI MOHAMMAD HOSSEIN; SHAHZADEH FAZELI ABOLHASSAN

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Journal: Koomesh Year:2014 | Volume:15 | Issue:3 (51) Page(s): 359-364

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Title

SURVEY ON CCR5-Δ32 MUTATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH CHRONIC HEPATITIS B REFERRED TO THE CLINICAL LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION

Author(s)

JALALI SAJJAD | SHARIFI ZOHREH | SANATI MOHAMMAD HOSSEIN | SHAHZADEH FAZELI ABOLHASSAN | Issue Writer Certificate

Keywords

CCR5Q2

CHRONIC HEPATITIS BQ2

MUTATIONQ3

Abstract

Introduction: CCR5 is one of the most important chemokine receptor involved in the recruitment of specific anti-viral immune cells to the liver. CCR5-D32 is a functionally null allele of CCR5 gene with a 32-bp deletion. Several studies have reported that this MUTATION may be associated with recovery from acute hepatitis B or persistence of HBV infection. The main purpose of this study was to compare the frequency of the D32 MUTATION within the CCR5 gene in a group of chronic HBV infected patients with healthy individuals in Iran.Materials and Methods: A total of 200 blood samples including 100 healthy individuals and 100 HBsAg positive patients were randomly selected. The samples were tested for HBsAg by ELISA and HBV-DNA by PCR method. Genomic DNA was extracted by salting out method. CCR5-D32 MUTATION was genotyped by PCR with specific primers.Results: The results of this study showed that none of the subjects in the control and patient groups had a 32-bp deletion in the CCR5 gene. CCR5-D32 was not a prevalent MUTATION in control group and HBV infected patients in Iran.Conclusion: No significant difference was observed in genotypes frequency of CCR5-D32 between control group and HBV infected patients, therefore it seems that this MUTATION is not associated with persistence of HBV infection in Iranian patients.

Cites

A STUDY ON THE ASSOCIATION BETWEEN CCRΔ32 MUTATION AND HCV INFECTION IN IRANIAN PATIENTS (SHORT COMMUNICATION)

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APA: Copy

JALALI, SAJJAD, SHARIFI, ZOHREH, SANATI, MOHAMMAD HOSSEIN, & SHAHZADEH FAZELI, ABOLHASSAN. (2014). SURVEY ON CCR5-Δ32 MUTATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH CHRONIC HEPATITIS B REFERRED TO THE CLINICAL LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION. KOOMESH, 15(3 (51)), 359-364. SID. https://sid.ir/paper/36827/en

Vancouver: Copy

JALALI SAJJAD, SHARIFI ZOHREH, SANATI MOHAMMAD HOSSEIN, SHAHZADEH FAZELI ABOLHASSAN. SURVEY ON CCR5-Δ32 MUTATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH CHRONIC HEPATITIS B REFERRED TO THE CLINICAL LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION. KOOMESH[Internet]. 2014;15(3 (51)):359-364. Available from: https://sid.ir/paper/36827/en

IEEE: Copy

SAJJAD JALALI, ZOHREH SHARIFI, MOHAMMAD HOSSEIN SANATI, and ABOLHASSAN SHAHZADEH FAZELI, “SURVEY ON CCR5-Δ32 MUTATION IN HEALTHY INDIVIDUALS AND PATIENTS WITH CHRONIC HEPATITIS B REFERRED TO THE CLINICAL LABORATORY OF IRANIAN BLOOD TRANSFUSION ORGANIZATION,” KOOMESH, vol. 15, no. 3 (51), pp. 359–364, 2014, [Online]. Available: https://sid.ir/paper/36827/en

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