EVALUATION OF PREVALENCE OF δ 32 MUTATION IN CCR5 GENE IN BREAST CANCER PATIENTS IN RAFSANJAN CITY

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KAZEMI ARABABADI M.; MIRZAEI MOHAMMAD REZA; REZAZADEH ZARANDI E.; HASANSHAHI GH.H.; VATANIBAF M.R.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2009 | Volume:19 | Issue:70 Page(s): 49-53

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Title

EVALUATION OF PREVALENCE OF δ 32 MUTATION IN CCR5 GENE IN BREAST CANCER PATIENTS IN RAFSANJAN CITY

Author(s)

Keywords

CHEMOKINEQ3

CCR5Q2

δ 32 AND BREAST CANCERQ3

Abstract

Background and purpose: CHEMOKINEs and their receptors are expressed in different types of malignancies. CC CHEMOKINEs MIP-1a (CCL3), MIP-1b (CCL4) and RANTES (CCL5) is believed to be anti-tumor and also aid to the metastasis in tumor microenvironment. CCR2 and CCR5 are special G-protein receptors for these CHEMOKINEs. Due to the important role of CCR5 CHEMOKINE receptor in tumor biology, this project is designed to examine d 32 mutation in CCR5 gene regards breast cancer.Materials and methods: This experimental study was performed during 2007-8 on 100 healthy adults and 36 breast cancer patients by Gap-PCR. The demographic information also was collected by questionner and t-test Chi-square was used for statistical analysis of data.Results: Our results showed that none of breast cancer patients had CCR5-d 32 mutation while 3 (3%) cases of controls had heterozygotic form of this mutation.Conclusion: Our results showed that there is not any CCR5-d 32 mutation in patients. Therefore, it appears that this mutation don’t play any role in breast cancer.

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APA: Copy

KAZEMI ARABABADI, M., MIRZAEI, MOHAMMAD REZA, REZAZADEH ZARANDI, E., HASANSHAHI, GH.H., & VATANIBAF, M.R.. (2009). EVALUATION OF PREVALENCE OF δ 32 MUTATION IN CCR5 GENE IN BREAST CANCER PATIENTS IN RAFSANJAN CITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(70), 49-53. SID. https://sid.ir/paper/44940/en

Vancouver: Copy

KAZEMI ARABABADI M., MIRZAEI MOHAMMAD REZA, REZAZADEH ZARANDI E., HASANSHAHI GH.H., VATANIBAF M.R.. EVALUATION OF PREVALENCE OF δ 32 MUTATION IN CCR5 GENE IN BREAST CANCER PATIENTS IN RAFSANJAN CITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(70):49-53. Available from: https://sid.ir/paper/44940/en

IEEE: Copy

M. KAZEMI ARABABADI, MOHAMMAD REZA MIRZAEI, E. REZAZADEH ZARANDI, GH.H. HASANSHAHI, and M.R. VATANIBAF, “EVALUATION OF PREVALENCE OF δ 32 MUTATION IN CCR5 GENE IN BREAST CANCER PATIENTS IN RAFSANJAN CITY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 70, pp. 49–53, 2009, [Online]. Available: https://sid.ir/paper/44940/en

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