EVALUATING THE ASSOCIATION OF CCR5-D32 MUTATION WITH TYPE 2 DIABETES IN RAFSANJANESE PATIENTS

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KAZEMI ARABABADI M.; NAGHAVI N.; HASANSHAHI GH.H.; SAJADI SEYED MOHAMMAD ALI

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Journal: Feyz Medical Sciences Journal Year:2009 | Volume:13 | Issue:3 (SERIAL 51) Page(s): 208-213

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Title

EVALUATING THE ASSOCIATION OF CCR5-D32 MUTATION WITH TYPE 2 DIABETES IN RAFSANJANESE PATIENTS

Author(s)

KAZEMI ARABABADI M. | NAGHAVI N. | HASANSHAHI GH.H. | SAJADI SEYED MOHAMMAD ALI | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

TYPE2Q3

RECEPTORSQ2

CCR5Q2

MUTATIONQ2

Abstract

Background: Although type-2 mellitus diabetes is the most common type of diabetes, it's main cause yet to be identified. Chemokines and their RECEPTORS are probable effective systems on diabetes. CCR5 is a chemokine receptor playing an important role in immune responses. Studies showed that the known d32 MUTATION in CCR5 gene leads to disorder in the expression and function of this receptor. Hence, this project aimed to analyze the known d32 MUTATION in CCR5 chemokine receptor.Materials and methods: Blood samples were collected from 200 type 2 diabetic patients and 300 healthy adult controls on EDTA pre-coated tubes. DNA was extracted using commercial kit. DNA samples were analyzed for d32 MUTATION by Gap-PCR in diabetic patients in compared to controls. The demographic information were collected through questionnaire.Results: Our results showed that none of the diabetic patients displayed CCR5 d32 MUTATION. While 2 out of 300 healthy controls had heterozigotic form of this MUTATION. Statistical analysis didn’t show any significant difference between the two groups. Conclusion: Several different studies analyzed the relation of this MUTATION with different types of diseases including diabetes. All studies failed to find a relation between this MUTATION and type 2 diabetes. Since these studies were performed in different geographical points and races, we studied this MUTATION in Rafsanjanese population. Based on the results of our study it could be probably concluded that this MUTATION does not play a key role in the establishment of type 2 diabetes.

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APA: Copy

KAZEMI ARABABADI, M., NAGHAVI, N., HASANSHAHI, GH.H., & SAJADI, SEYED MOHAMMAD ALI. (2009). EVALUATING THE ASSOCIATION OF CCR5-D32 MUTATION WITH TYPE 2 DIABETES IN RAFSANJANESE PATIENTS. FEYZ, 13(3 (SERIAL 51)), 208-213. SID. https://sid.ir/paper/394714/en

Vancouver: Copy

KAZEMI ARABABADI M., NAGHAVI N., HASANSHAHI GH.H., SAJADI SEYED MOHAMMAD ALI. EVALUATING THE ASSOCIATION OF CCR5-D32 MUTATION WITH TYPE 2 DIABETES IN RAFSANJANESE PATIENTS. FEYZ[Internet]. 2009;13(3 (SERIAL 51)):208-213. Available from: https://sid.ir/paper/394714/en

IEEE: Copy

M. KAZEMI ARABABADI, N. NAGHAVI, GH.H. HASANSHAHI, and SEYED MOHAMMAD ALI SAJADI, “EVALUATING THE ASSOCIATION OF CCR5-D32 MUTATION WITH TYPE 2 DIABETES IN RAFSANJANESE PATIENTS,” FEYZ, vol. 13, no. 3 (SERIAL 51), pp. 208–213, 2009, [Online]. Available: https://sid.ir/paper/394714/en

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