Identification of Fibrinolytic Activity in Iranian Vipera Lebetina Venom

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AMOOZGARI ZOHREH; CHERAGHZADEH MARYAM; NOORBEHBAHANI MOZHGAN; LAMUCHI DELI NASRIN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:30 | Issue:188 Page(s): 17-25

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Title

Identification of Fibrinolytic Activity in Iranian Vipera Lebetina Venom

Author(s)

AMOOZGARI ZOHREH | CHERAGHZADEH MARYAM | NOORBEHBAHANI MOZHGAN | LAMUCHI DELI NASRIN | Issue Writer Certificate

Keywords

Vipera lebetina venomQ1

coagulant activityQ1

anticoagulant activityQ1

endopeptidaseQ1

arginine esteraseQ1

fibrinolysisQ1

Abstract

Background and purpose: Vipera lebetina lives in different areas in Iran, and its venom contains a variety of proteins with coagulant and anticoagulant activities. Fibrinolytic enzymes could have a therapeutic role in dissolution of blood clots, so, this study aimed at separating the venom components of Iranian V. lebetina and detecting its anticoagulant activity. Materials and methods: In this experimental study, crude venom components were isolated by gel filtration chromatography on sephadex G-100. We investigated the endopeptidase, arginine ester hydrolase, coagulant, anticoagulant, and fibrinolytic activities in crude venom and separated fractions. Results: The crude venom was separated into five fractions (PI-PV). 200 mg of crude venom contained 187 mg protein and 11. 75 mg protein was recovered from 187 mg protein used on the column. The venom showed coagulant activity at low concentrations and anticoagulant activity at high concentrations. endopeptidase activity was detected in crude venom and all fractions except PV. Also, arginine ester hydrolase activity was seen in crude venom, PI, and PII. Fibrinolytic activity was found in crude venom and only in PIII. Conclusion: According to this study, the venom of Iranian V. lebetina has strong proteolytic activities including fibrinolytic that dissolve blood clots by lysis fibrin directly in laboratory conditions.

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APA: Copy

AMOOZGARI, ZOHREH, CHERAGHZADEH, MARYAM, NOORBEHBAHANI, MOZHGAN, & LAMUCHI DELI, NASRIN. (2020). Identification of Fibrinolytic Activity in Iranian Vipera Lebetina Venom. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(188 ), 17-25. SID. https://sid.ir/paper/368776/en

Vancouver: Copy

AMOOZGARI ZOHREH, CHERAGHZADEH MARYAM, NOORBEHBAHANI MOZHGAN, LAMUCHI DELI NASRIN. Identification of Fibrinolytic Activity in Iranian Vipera Lebetina Venom. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(188 ):17-25. Available from: https://sid.ir/paper/368776/en

IEEE: Copy

ZOHREH AMOOZGARI, MARYAM CHERAGHZADEH, MOZHGAN NOORBEHBAHANI, and NASRIN LAMUCHI DELI, “Identification of Fibrinolytic Activity in Iranian Vipera Lebetina Venom,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 188 , pp. 17–25, 2020, [Online]. Available: https://sid.ir/paper/368776/en

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